RESUMO
We experimentally demonstrated dual-wavelength synchronous operation of a high-power passively mode-locked 2-µm Tm:CaYAlO4 (Tm:CYA) disordered crystal laser with semiconductor saturable absorber mirror (SESAM) as mode locker. The mode-locked laser emitted an average output power as high as 830 mW with pulse duration of 35.3 ps and repetition rate of 145.4 MHz. The mode-locking dual wavelengths were centered at 1958.9 nm and 1960.6 nm, respectively. Autocorrelation trace clearly shows beating pulses with pulse width of 3.5 ps and repetition rate of 0.13 THz.
RESUMO
We report three cases of homozygous alpha-thalassemia (alphaTH) who survived beyond the neonatal period, all with hypospadias. A review of literature identified two additional male cases of homozygous alphaTH who survived, and both had hypospadias. The simultaneous occurrence of the two conditions seems beyond coincidence and may be causally related. Possible pathogenesis for the association may be 1) homozygous alphaTH-induced in utero and/or edema secondary to hydrops fetalis, both leading to the failure of proper fusion of the urogenital folds, or 2) defect of another gene located at a chromosome 16p13.3 region. Thus, parents who request intrauterine therapy for a male fetus with homozygous alphaTH should be informed about this association and its prognosis.
