Tribological Properties of a Sliding Joint with an a-C:H:W Coating under Lubrication Conditions with PAO8 Oil and the Addition of 2% MoS2 Nanoparticles.

One of the promising methods for improving the durability and reliability of friction joints in combustion engines is the use of thin and hard coatings, including coatings based on amorphous DLC. The a-C:H:W coating was produced using the commercial PVD method. The tested tribological joints were made of AISI 4337 steel and SAE-48 bearing alloy (conformal contact) and AISI 4337 steel and valve shims (non-conformal contact). The contact area was lubricated with SAE 5W40 engine oil and PAO8 oil + 2 wt.% MoS2 nanoparticles. The objective of this work is to explore the influence of PAO8 + MoS2 on the tribological properties of a sliding joint with an a-C:H:W coating and the change in the properties of the oils. In the conformal contact, the lubrication of the a-C:H:W coating with PAO8 + MoS2 caused a significant increase in the friction resistance (than in) as compared to the joints with a quenching and tempering surface layer and lubricated SAE 5W40, while in the non-conformal contact, the lubrication of the a-C:H:W coating with PAO8 + MoS2 caused a decrease in the friction resistance and temperature of the contact area. The joints with the a-C:H:W coating were characterized by higher wear of the SAE-48 bearing alloy, as compared to the joints with the surface layer without coating (lubricated with SAE 5W40 oil-11-fold increase, PAO8 + MoS2-46-fold increase). The wear of valve shims with the a-C:H:W coating was significantly lower as compared to the wear of the commercial version of the valve shims (the difference between joints lubricated with SAE 5W40 oil and PAO8 + MoS2 was 12%, 36% and 29% for unit pressures of 10, 15 and 20 MPa). Lubrication of the a-C:H:W coating with PAO8 oil + MoS2 protected the sliding joints against seizing in non-conformal contact.

Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas--implication for clinical evaluation of cancer patient.

The presence of lymph node metastasis (LNM) is an important factor in clinical evaluation of esophageal cancer patients. Biological markers able to support detection of metastatic lymph nodes are sought after. Interleukin-8 (IL-8) is overexpressed by many cancers and involved in cancer dissemination. We investigated the relationship between circulating IL-8 and clinicopathological features of esophageal squamous cell carcinoma (ESCC), and evaluated the diagnostic potential of IL-8, with reference to the key angiogenic and lymphangiogenic factors: vascular endothelial growth factors A and C (VEGF-A and VEGF-C). We found elevated IL-8 levels in ESCC patients, correlated with tumor size and cancer dissemination, especially LNM. Circulating IL-8 correlated with lymphangiogenic VEGF-C rather then angiogenic VEGF-A. The association weakened in metastatic cancers, suggesting divergent mechanism of IL-8 involvement in the dissemination process. The cytokine levels correlated with platelets and neutrophils, pointing at these cells as possible sources of circulating IL-8. We demonstrated IL-8 that positively correlated with inflammation status of ESCC patients. Circulating IL-8 was a better indicator of ESCC dissemination than VEGF-A or VEGF-C. Yet, the detection rates were not satisfactory enough to allow for the recommendation of IL-8 determination as an adjunct to the clinical evaluation of lymph node involvement in ESCC patients.