RESUMO
The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.
Assuntos
Envelhecimento/fisiologia , Peroxidação de Lipídeos/fisiologia , Isquemia Miocárdica/fisiopatologia , Receptores Adrenérgicos/fisiologia , Adulto , Idoso , Envelhecimento/sangue , Envelhecimento/efeitos dos fármacos , Benactizina/uso terapêutico , Bochecha , Eletrofisiologia , Membrana Eritrocítica/efeitos dos fármacos , Membrana Eritrocítica/fisiologia , Feminino , Humanos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/citologia , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/fisiologia , Isquemia Miocárdica/sangue , Isquemia Miocárdica/tratamento farmacológico , Receptores Adrenérgicos/efeitos dos fármacosRESUMO
A study is presented of the main microcirculation values in comparison with systemic hemodynamics in patients with chronic circulatory insufficiency under the effect of complex therapy with dilanacin + corinfar and clift + corinfar. It was established that calcium antagonists reduce postloads and, thus, facilitate the cardiac work in overcoming general peripheral resistance of blood vessels supplementing the effect of cardiac glycosides in the direction of improvement of myocardial inotropism and increase of its propulsive force.