QUANTITATIVE MORPHOLOGICAL ASPECTS OF THE STUDY OF THE FEATURES OF THE REMODELING OF THE HEMOMICROCIRCULATORY CHANNEL OF THE TESTICLES UNDER THE ACTION OF ALUMINUM CHLORIDE ON THE BODY.

OBJECTIVE: The aim: To conduct a morphometric analysis of the features of the remodeling of vessels of the hemomicrocirculatory channel of the testicles under the action of aluminum chloride on the body. PATIENTS AND METHODS: Materials and methods: The testicles of 52 white male Wistar rats were morphologically studied, which were divided into two groups: intact and animals injected with aluminum chloride at a dose of 100 mg/kg. RESULTS: Results: The long-term effect of aluminum chloride on the body led to pronounced changes in the quantitative morphological indicators of the vessels of the hemomicrocirculatory channel of the testes compared to the control ones. The diameter of arterioles of the left testicle decreased by 18.4%, precapillary arterioles by 19.1%, hemocapillaries by 10.1%. The diameter of the postcapillary venules of the left testicle increased by 26.3%, the venules by 26.4%, and the density of microvessels decreased by 30.0%, which indicated the deterioration of its blood supply. The degree of remodeling of microvessels in the right testis was less pronounced. The diameter of arterioles of the right testicle decreased by 17.1%, precapillary arterioles by 18.4 %, and hemocapillaris by 9.1%. The diameter of the postcapillary venules of the right testicle increased by 25.5%, the venules by 27.0%, and the density of microvessels decreased by 25.8%. CONCLUSION: Conclusions: Long-term action (during the month) of aluminum chloride on the body leads to pronounced remodeling of the vessels of the hemomicrocirculatory channel of the testicles, which is characterized by a pronounced narrowing of its supply (arterioles, precapillary arterioles), exchange (hemocapillaries) links.

Analysis of patients' rehabilitation results after surgical treatment of diabetes complications.

The results of treatment of patients with diabetic foot syndrome (DFS) remain unsatisfactory, 34% of patients have another wound defect in the foot within 1 year, and the recurrence rate within 5 years is 70%. AIM: The aim of the study was to determine the indicators of physical capabilities and self-care of patients after organ-sparing surgery due to DFS. MATERIALS AND METHODS: 6-12 months after discharge from the surgical hospital, all patients were sent questionnaires of the functional scale of the lower extremities. The questionnaire consists of 20 questions related to physical difficulties associated with the function of the lower extremities. The answers were evaluated on a scale: inability to perform actions - 0 points, in the absence of difficulties, the score was 4 points. RESULTS: 87.4% of responses to 176 letters were received, of which 84.6% contained answers to questionnaires, and 2.8% reported relatives' deaths. Despite self-monitoring of glycemia, 7 out of 10 patients did not reach its target level. When assessing physical activity in everyday life associated with the condition of the lower extremities after surgery, the indicator in the study group was 32.17 ± 17.88 points, and in the control group - 34.71 ± 16.13 points. The lowest mean score, 20.45 ± 11.53 was found in the group of patients after "high" amputations. The estimated score of self-care within the apartment was below 12 in 3 (27.2%) patients from the group after "high" amputations and was 13.27 ± 4.53, and in patients after operations within the foot - 15.71 ± 5 , 51 points. With limited physical activity, patients adjust satisfactorily to simple home activity within the home. CONCLUSIONS: Indicators of physical capabilities and self-care of patients after organ-sparing operations for DFS do not differ significantly from those in patients without this syndrome. The ability to perform physical activities within the home is influenced by the duration of diabetes, the presence of circulatory failure, decreased vision, as well as overweight patients.