[Assessment of the metastatic potential of localized forms of colorectal cancer]. / Otsenka metastaticheskogo potentsiala lokalizovannykh form kolorektal'nogo raka.

OBJECTIVE: To assess the risk of recurrence after surgical treatment is an integral part of the management of patients with colorectal cancer. The AJCC/UICC TNM staging system, in which the risk is identified by grouping the patients on the basis of anatomical elements, is commonly used. Despite the simplicity of implementation, significant heterogeneity remains within each stage group. A better tool for predicting a recurrence is needed in the era of multimodal treatment. SUBJECTS AND METHODS: A total of 1350 archival colorectal cancer cases during 2012 to 2015 were retrospectively analyzed; among which the investigators identified 3 patient groups: 1) 53 patients with non-metastatic colon cancer for at least 5 years; 2) 45 patients with metachronous metastases detected during the same period; and 3) 53 patients with synchronous metastases. Among the estimated 31 parameters, the investigators used a multidimensional analysis to select 6 most significant prognostic factors that were included in the final model based on a logistic regression analysis. The resulting model was applied to assess the risk of metastasis after cytoreductive surgery. It was internally and externally validated in an examination group (n=25). RESULTS: The model has a sensitivity of 97.78% and a specificity of 96.23%, improving the risk stratification for metastatic colon cancer. The factors in the model include extramural venous invasion, the severity of budding, the expression of E-cadherin and ß-catenin, the proportion of cytotoxic CD8+ lymphocytes of the total number of T lymphocytes in the microenvironment, and the ratio of newly formed vessels to tumor stromal microvessel density. CONCLUSION: Using morphopathological factors, the resulting model allows better consideration of tumor specificity in a particular patient, thereby providing a more individual prediction of outcome than that provided by the AJCC/UICC TNM staging system. By identifying patients at both high- and low-risk for metastasis, the model can be useful to plan treatment and to choose clinical management tactics for patients with colorectal cancer.

A new species of Phyllotreta Chevrolat, 1836 (Coleoptera: Chrysomelidae: Galerucinae: Alticini) from Omsk Province of Russia with comments on Phyllotreta species diversity in Northeastern Palearctic.

A new species of flea beetle genus Phyllotreta Chevrolat, 1836 (P. sholaksori new species) is described from shores of saline lakes in Southwestern Siberia. It is compared with species with which it was collected as well as with species comprising a group to which it belongs (P. araxicola Jablokoff-Khnzorian, 1968, P. astrachanica Lopatin, 1977, P. atra Fabricius, 1775, P. balcanica Heikertinger, 1909, P. cruciferae Goeze, 1777, and P. diademata Fourdas, 1860). All these species are illustrated and included in the key.

[Ectopic adrenal cortical adenoma in the spinal canal: A case report and a review of the literature]. / Ektopicheskaya adrenokortikal'naya adenoma pozvonochnogo kanala: nablyudenie iz praktiki i obzor literatury.

Ectopic adrenal cortical neoplasms are extremely rare. The authors describe their own case of intradural, extramedullary conus medullaris adenoma that occurred in a 55-year-old woman, which was clinically accompanied by lumbar pains, left leg numbness, and left foot weakness during 10 years. The mass was histologically composed of rounded and polygonal cell fields with rounded, regular nuclei and abundant eosinophilic and clear cytoplasm. There were no necroses or mitoses. The cells were immunohistochemically positive for cytokeratin AE1/3, vimentin, inhibin-α, melan-A, and synaptophysin. An ectopic adrenocortical adenoma was diagnosed after ruling out myxopapillary ependymoma, meningioma with oncocytic transformation, paraganglioma, metastatic renal cell carcinoma, and adrenal cortical carcinoma. In the opinion of most investigators, extra-adrenal tumors develop from ectopic adrenal cortical tissue. To date, only eight intraspinal adrenal cortical tumors have been described. These tumors should be considered in the differential diagnosis of central nervous system masses located in the lower spinal canal.

New genus and species of flea beetles (Coleoptera, Chrysomelidae, Galerucinae, Alticini) from Puerto Rico, with comments on flea beetle diversity in the West Indies and a key to the West Indian Monoplatini genera.

A new genus (Borinken) and five new species (Borinken elyunque, Distigmoptera chamorrae, Kiskeya elyunque, Ulrica eltoro, and Ulrica iviei) from Puerto Rico are described and illustrated. A keyto all West Indian Monoplatini genera is provided, as are keys to all speciesof Kiskeya and to the speciesof Ulrica from Puerto Rico. A list of the flea beetle genera, along with the number of species and some of the faunal features is presented and discussed for the West Indies.

[The effect of the fluctuations of abiotic factors on the metabolism of some hydrobionts]. / Vliianie kolebanii abioticheskikh factorov na metabolizm nekotorykh gidrobiontov.

It has been shown that slight sinusoidal fluctuations of temperature, salinity, and oxygen concentration optimize the growth and energy metabolism of the crustacean Leander modestus, mollusks Pila sp., and hydrophyte Elodea canadensis. Under the effect of temperature fluctuations, the growth of E. canadensis accelerates, and the rate of photosynthesis increases.

[Effect of lighting oscillations on growth and energetics of the goldfish Carassius auratus]. / Vliianie kolebanii osveshchennosti na rost i énergetiku zolotoi rybki Carassius auratus.

Periodic oscillations of illumination exert a positive, rather than negative, effect on goldfish growth and energetics. In a variable light regime, the fishes grow of a higher rate, have decreased oxygen and food requirements, improve the utilization of consumed food for growth, and decrease the oxygen expenditure per increment of unit body mass. The goldfish reactions to the frequency of illumination oscillation and the succession of the stationary light regime by the oscillatory regime were described.