Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.

Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles.

[West Indians in the Netherlands: prospects of return]. / Les Antillais aux Pays-Bas: perspectives de retour.

The return migration policy of the Netherlands and the probability of its success are assessed, with the focus on migrants from the Netherlands Antilles. Factors associated with return migration are studied using data from a sample survey and from other published sources. Age, educational status, and social welfare in the Netherlands show significant correlations with desire to return to the Netherlands Antilles. "Those who have actually returned belong to the higher social strata of the migrant group; having a job in the West Indies matters much more to them than housing conditions.... It is concluded that the Netherlands should increase their financial contribution to the system of social welfare in the West Indies and even more so to the economic development of these islands." (SUMMARY IN ENG)