[Metabolic responses to ergometry and their role in the development of physical work capacity in patients with ischemic heart disease and different types of hemodynamics]. / Metabolicheskie reaktsii pri érgometrii i ikh rol' v formirovanii fizicheskoi rabotosposobnosti u bol'nykh ishemicheskoi bolezn'iu serdtsa s razlichnymi tipami gemodinamiki.

Blood coagulation and fibrinolysis, lipid and lactate levels and some enzyme activities were measured in 283 coronary patients during bicycle ergometry. Hemodynamic type was established on the basis of the cardiac index. A negative correlation is demonstrated between the cardiac output and blood lipids. Fibrinolytic reserve was intact in 32.3% of patients with eu- and hyperkinetic hemodynamic types and in just 9.3% of patients with hypokinetic hemodynamics. The latter type was associated with the greatest disturbance of aerobic/anaerobic metabolism ratios. The extent of disturbance in lipid metabolism and blood coagulation is closely correlated with hemodynamic types that reflect the state of myocardial contractility.

[Multifactorial analysis of the physical work capacity of patients with chronic ischemic heart disease]. / Mnogofaktornyi analiz fizicheskoi rabotosposobnosti u bol'nykh khronicheskoi ishemicheskoi bolezn'iu serdtsa.

A series of 512 patients with coronary heart disease were examined using a complex of clinical, instrumental and biochemical methods. The capacity for physical work was determined by bicycle ergometry. Fifty-four signs were studied in relation to the exercise tolerance. On the basis of the findings about the closeness of the correlation between these signs and the patients' capacity for physical work, 19 prognostically significant criteria were identified. A multi-factorial clinico-functional and biochemical classification of coronary heart disease patients with regard to three levels of the capacity for physical work was elaborated which made it possible to develop a method of the complex assessment and prediction of the capacity for physical work.

[Physical work capacity of ischemic heart disease patients with various types of hyperlipoproteinemias]. / Fizicheskaia rabotosposobnost' bol'nykh ishemicheskoi bolezn'iu serdtsa s razlichnymi tipami giperlipoproteidemii.

The results of ergometric examination of 316 patients with chronic coronary insufficiency and various types of hyperlipoproteinemia have shown a clear diminution of physical working capacity in patients with hyperlipidemia as compared to patients with hyperlipidemia as compared to patients in whom the lipid content is within normal values. Working capacity was most diminished in IIa and particularly IIb types of hyperlipoproteinemia; in type IV physical working capacity was not reduced. The effect of hyperlipoproteinemia is most significant in the mildest degree of coronary insufficiency, but reduces or vanishes completely with increasing severity of the disease. An inverse relationship has been established between the value of physical working capacity and the level of cholesterol and beta-lipoproteins and a direct relationship in regard to NEFA concentration. Ergometry in patients with type II hyperlipoproteinemia showed that as compared to patients with normolipemia and type IV hyperlipoproteinemia an equal degree in the severity of the disease, the frequency and marked character of changes on the ECG increase; this evidences a more marked transitory myocardial ischemia.

[Effect of physical exercises on certain indicators of lipid metabolism in patients with hypertensive disease and renal hypertension]. / Vliianie fizicheskikh nagruzok na nekotorye pokazateli lipidnogo obmena u bol'nykh gipertonicheskoi bolezn'iu i pochechnoi gipertoniei

The effect of physical exercises was studied with reference to the content of non-esterified fatty acids (NEFA), cholesterol and beta-lipoproteins, as well as catecholamines and lactic acid in 130 patients with essential and renal hypertension. The control group included 12 normal individuals. The physical exercises were conducted on a bicycle ergometer with a step-wise growth of the load by 150-300 kgm per each 4 min. The value of the maximal tolerated physical load was determined. It was decreasing parallel the progress of the disease. The conducted investigations demonstrated the presence of an inverse relationship between the initial blood level of beta-lipoproteins and cholesterol, on the one hand, and the value of physical load and capacity for work, on the other. The changes in the lipid metabolism parameters are distinctly connected with the activity of catecholamines and lactate concentration.