RESUMO
cAMP and cGMP contents were studied in various eye tissues of rabbits with experimental glaucoma induced by chronic intravenous adrenaline administration. Cyclic nucleotide level was measured in the retina, choroid, iris and ciliary body. An increase in the tissue cAMP level was found especially in the iris and ciliary body. An increase in tissue cAMP content is explained by an enhanced beta-adrenergic regulation in the eyes of rabbits with experimental glaucoma. No consistent changes were found in cGMP content in eye tissues.
Assuntos
AMP Cíclico/análise , GMP Cíclico/análise , Olho/análise , Glaucoma/metabolismo , Animais , Corioide/análise , Corpo Ciliar/análise , Epinefrina , Glaucoma/induzido quimicamente , Glaucoma/fisiopatologia , Iris/análise , Coelhos , Receptores Adrenérgicos beta/fisiopatologia , Retina/análiseRESUMO
It has been shown in experiments on rabbits that alpha-and beta-adrenoblockers, and lithium chloride solution exert different effect on intraocular tension of healthy animals with experimental glaucoma and transitory hypertension. The beta-blockker obsidan decreases the tension in experimental glaucoma. Pretreatment with the drug prevents the development of glaucoma. On the contrary, the alpha-blocker pirroxan promotes the development of glaucoma and does not elicit any hypotensive therapeutic effect. The drug-induced decrease in intraocular tension was recorded in healthy animals and in rabbits with transitory hypertensin of the eye. The hypotensive effect of lithium was noted only in the animals with experimental glaucoma. The role of alpha-and beta-adrenergic receiption in the pathogenesis of glaucoma is discussed.
