Optimization of an optrode microdevice for infrared neural stimulation.

Infrared light is a promising candidate for the treatment of neurodegenerative diseases. Optimizing the device parameters to achieve the best optical and mechanical performance is essential for reliable in vivo operation. In this work, mechanical strength simulations and coupled optical and thermal model were used to determine optimal design parameters for maximizing overall device efficiency. Our analysis reveals that minimizing the number of integrated optical elements and optimizing the optical path leads to a 33% relative in-coupling efficiency improvement at equal mechanical robustness. Using a symmetric optrode tip with an angle of 15°, the efficiency showed a further 17% relative improvement due to the enhancement of out-coupling at the tip. To investigate the temperature rise of the brain tissue during the infrared stimulation in the case of the optimized device, a thermal simulation with pulsed infrared excitation was developed. Our results show that the optimized device provides a temperature rise of 4.42°C as opposed to 3°C for the original setup.

Optical and thermal modeling of an optrode microdevice for infrared neural stimulation.

Infrared neural stimulation is a promising medical technique using pulsed infrared light for generating temperature-controlled firing of neurons. A combined optical and thermal model of a stimulating microtool-or so-called optrode-has been developed to investigate the amount, the spatial distribution, and the temporal behavior of the thermal excitation. Ray tracing and Fourier optics were used to describe the propagation and scattering of light in the optrode, and the finite element method was applied to model heat transfer. The scattered intensity distribution profiles were calculated based on measured surface roughness of the device and were integrated into the ray optics model. As a validation of the optical model, the simulated and measured values of the light efficiency of the microoptical system are compared. The temperature rise of the brain tissue during the infrared stimulation was estimated using the combined model. Using 30 mW total power and a single 100 ms pulse, the excitation resulted in a temperature rise of 3°C of the brain tissue. The spatial and temporal distributions of the tissue temperature are discussed in the paper. The proposed combined model is an efficient tool for the investigation and optimization of the stimulation process and for further development of the optrode configuration.

Simulation of small- and wide-angle scattering properties of glass-bead retroreflectors.

Retroreflective materials are extensively used as traffic signs and security patterns. These goods are often realized by spherical glass-beads attached to some reflective substrate. New applications, especially 3D projection, require the precise evaluation and design of the characteristics of light backscattered from retroreflective screens. Simulation of such materials is not straightforward due to the different optical processes taking place: direct retroreflection involving small-angle diffraction effects, and multiple scattering resulting in wide-angle diffuse light. We propose a new complex method to describe the backscattering properties of glass-bead retroreflectors that uniquely combines diffraction calculations with ray tracing based on the microscopic properties of the screen. We validated our simulation method by measurements performed on commercial retroreflective samples.

Modeling material saturation effects in microholographic recording.

Microholographic data storage system model is presented that includes non-linear and non-local behavior of the storage material for accurate simulation of the system and optimization of the writing process. For the description of the photopolymer material a diffusion based nonlocal material model is used. The diffusion equation is solved numerically and the modulation of the dielectric constant is calculated. Diffraction efficiency of simulated microholograms and measurements were compared, and they show good agreement.

Demonstration of optically controlled data routing with the use of multiple-quantum-well bistable and electro-optical devices.

We present experimental results on a 1-to-64-channel free-space photonic switching demonstration system based on GaAs/GaAlAs multiple-quantum-well active device arrays. Two control schemes are demonstrated: data transparent optical self-routing usable in a packet-switching environment and direct optical control with potential signal amplification for circuit switching. The self-routing operation relies on the optical recognition of the binary destination address coded in each packet header. Address decoding is implemented with elementary optical bistable devices and modulator pixels as all-optical latches and electro-optical and gates, respectively. All 60 defect-free channels of the system could be operated one by one, but the simultaneous operation of only three channels could be achieved mainly because of the spatial nonhomogeneities of the devices. Direct-control operation is based on directly setting the bistable device reflectivity with a variable-control beam power. This working mode turned out to be much more tolerant of spatial noises: 37 channels of the system could be operated simultaneously. Further development of the system to a crossbar of N inputs and M outputs and system miniaturization are also considered.