[Increase in radiation resistance of an organism after administration of metabolic drug MR-33]. / Povyshenie radiorezistentnosti organizma pri deistvii metabolitnogo preparata MR-33.

Original MP-33 metabolic drug has inductive action on intracellular levels of glutathione (GSH) and GSH-related enzymes (glutathione peroxidase-GPx, glutathione S-transferase-GST) of animals and human (liver, heart, erythrocytes). Treatment of Wistar male rats with MP-33 per os (6 mg/kg) 30 min before gamma-irradiation with a dose of 7 Gy results in 35% survival and increasing of mean life. In "mother-foetus" system the induction of intracellular level of GSH, GST and GPx by MP-33 leads to enhancement of foetus radioresistance. In contrast to MP-33 us of GSH (6 and 100 mg/kg) is not effective. Perspective of MP-33 us in relation to radioecological crisis is discussed.

[The corrective action of limontar in metabolic disorders in the mother-fetus system caused by ethanol exposure during pregnancy]. / Issledovanie korrigiruiushchego deistviia limontara pri obmennykh narusheniiakh v sisteme mat'--plod, vyzvannykh vozdeistviem étanola vo vremia beremennosti.

It was established in experiments on nonbred albino rats that injection of limontar (1 mg/kg) in the fetal period of pregnancy in alcoholic intoxication (6 g/kg) leads to weight loss by the female, normalization of the character of behavior and metabolic shifts in the organism, and removal of the symptoms of excitation of the sympathetic link of cardiovascular system regulation. No harmful effect of limontar on the mother-fetus biosystem was detected.

[New possibilities for metabolic protection from hypoxia in pregnant rats and their progeny]. / Novye vozmozhnosti metabolicheskoi zashchity ot gipoksii beremennykh krys i ikh potomstva.

Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent. Its administration during the last third of pregnancy stimulated the organism's protective-adaptational reactions, increased the resistance of pregnant, rats and the newborns to hypoxia. Limontar significantly improves the mechanometabolic indices of an isolated perfused heart under hypoxic conditions. Analysis of the obtained data suggests that limontar increases energy formation in the myocardium through activation of a more efficient and energetically beneficial path of succinic acid oxidation.

[The corrective properties of glycine in alcoholic intoxication in the fetal period of pregnancy]. / Korrigiruiushchie svoistva glitsina pri alkogol'noi intoksikatsii v plodnyi period beremennosti.

Natural metabolite glycine administered per os to rats in the fetus period of pregnancy in a dose of 1 mg/kg was found to exert a corrective action with respect to the toxic effect of ethanol in the mother-fetus system. Glycine prevents loss in the body weight, normalizes functional state of the nervous system and metabolic disorders in the maternal organism, improve the redox processes in the lymphocytes changed under alcoholization, and protect the fetus both on the metabolic and microstructural levels.

[The protective action of limontar in pregnant animals with acute hypoxic hypoxia]. / Protektornoe deistvie limontara na beremennykh zhivotnykh pri ostroi gipoksicheskoi gipoksii.

A comparative study of individual resistance of rats to acute hypoxic hypoxia was performed. It was shown that individual resistance of the organism to hypoxia significantly decreases in the course of pregnancy. Limontar is shown to be active antihypoxant. Limontar administered during the last third of pregnancy stimulates protective-adaptive reactions in the females, thus increasing their resistance to hypoxia.

[Dependence of the embryotoxic action of dioxidine and cyclophosphamide on the immunoreactivity of the maternal-fetal system in mice]. / Issledovanie zavisimosti émbriotokischeskogo deistviia dioksidina i tsiklofosfamida ot immunoreaktivnosti sistemy mat'-plod u myshei.

It has been shown that the embryotoxic action of cyclophosphamide and dioxydin (an antibacterial drug) was more pronounced upon syngeneic than upon reciprocal crossing of CBA and C57BL/6 mice. Preliminary (21 days before crossing intrauterine sensitization of C57BL/6 mice with syngeneic or allogeneic lymphocytes obtained from males' spleen led to the attenuation of the embryotoxic action of cyclophosphamide and dioxydin. During sensitization with allogeneic lymphocytes, the embryotoxic action was attenuated more appreciably. Extirpation of the paraaortal lymph nodes in female C57BL/6 mice performed 14-15 days before crossing potentiated the embryotoxic action of cyclophosphamide in the case of allogeneic crossing of females. Upon syngeneic crossing of females with the extirpated paraaortal lymph nodes the intensity of the embryotoxic action of cyclophosphamide remained unchanged. It is concluded that the immune status of the mother-embryo system can, under the definite conditions, determine the intensity of the embryotoxic action of xenobiotics on the mammals.