RESUMO
The in vitro study of the influence of photodynamic action (with the use of photosensitizer "Photosens", laser and non-laser irradiation) on the strains of the main representatives purulent wound microflora was carried out. Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis cultures have been isolated from wound secretions and identified. The photosensitizer was shown to produce no bactericidal effect by itself. Irradiation with laser and non-laser light sources induced a sharp decrease in the number of viable cells in the cultures under study. The irradiation of the photosensitizer led to its activation, manifested in bactericidal action. The results thus obtained confirm good prospect of using photodynamic therapy for the treatment of purulent wounds.
Assuntos
Bactérias/efeitos da radiação , Indóis/farmacologia , Lasers , Luz , Compostos Organometálicos/farmacologia , Fármacos Fotossensibilizantes/farmacologia , Ferimentos e Lesões/microbiologia , Bactérias/crescimento & desenvolvimento , Bactérias/isolamento & purificação , Contagem de Colônia Microbiana , FotoquimioterapiaAssuntos
Fotoquimioterapia , Fármacos Fotossensibilizantes/uso terapêutico , Infecções dos Tecidos Moles/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estreptocócicas/tratamento farmacológico , Células Cultivadas/efeitos dos fármacos , Fotorradiação com Hematoporfirina , Humanos , Indóis/uso terapêutico , Isoindóis , Compostos Organometálicos/uso terapêutico , Supuração/tratamento farmacológico , Compostos de ZincoRESUMO
Clinical and histological examinations of 1562 patients with trophic and advanced radiation ulcers were carried out during 30 years. Malignant transformation of the ulcers has been revealed in 14 of them: sarcoma--in 1, and cancer--in 13. From all the patients with advanced radiation ulcers, malignant transformation was detected in 7.07%, and in cases of ulcers of the other genesis--in 0.81% of cases. Malignant transformation of ulcers of non-radiation genesis occurs on the average after 19 years, and of radiation one--after 3.8 years. Early diagnosis of skin cancer, at the site of the ulceris rather difficult and depends thoroughly on oncological alert and timely morphological examination of various skin areas. A new, rather perspective and relatively simple method of treatment for ulcerative forms of cancer of the skin is photodynamic therapy (PhDT). This method showed to be effective even in those patients who failed conventional methods of treatment (relapses), or had contraindications. PhDT has broaden the armory of the oncologists and oncodermatologists for treatment of complicated forms of cancer of the skin.