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1.
J Clin Psychiatry ; 50(5): 174-7, 1989 May.
Artigo em Inglês | MEDLINE | ID: mdl-2715140

RESUMO

Twenty-six of 100 consecutively admitted schizophrenic or schizoaffective patients required seclusion during their hospital stays. Seclusion episodes usually involved involuntarily committed, severely ill patients and occurred early in their hospitalizations. The recollections of the personal seclusion experiences of 17 patients were generally factually accurate, except for a tendency to play down disruptive aggressive behavior on their part. Patients described seclusion as a painful experience associated with feelings of helplessness, fear, sadness, and anger. However, patients also stated that seclusion rooms were necessary on inpatient psychiatric units and that the rooms were used for the control of disruptive aggressive patient behaviors. This study highlights not only the need for staff to clarify for patients what behavior has led to seclusion and what behavior will lead to release, but also the need for staff to acknowledge patients' distress at the experience.


Assuntos
Atitude Frente a Saúde , Hospitalização , Esquizofrenia/terapia , Isolamento Social , Adulto , Agressão , Internação Compulsória de Doente Mental , Feminino , Humanos , Masculino , Aceitação pelo Paciente de Cuidados de Saúde , Transtornos Psicóticos/psicologia , Transtornos Psicóticos/terapia , Psicologia do Esquizofrênico , Percepção do Tempo
2.
Respiration ; 51(4): 277-84, 1987.
Artigo em Inglês | MEDLINE | ID: mdl-3310159

RESUMO

The bronchoprotective effect of bioequivalent doses of theophylline (TH; 234 mg) and a combination of TH, proxyphylline (PPH) and diprophylline (DPH) in the proportion 2:3:3 (Neo-Biphyllin, NB; 600 mg) against carbachol-induced bronchoconstriction was studied in 10 healthy non-smokers in a randomised controlled double-blind cross-over trial. The subjects were on a methylxanthine-free diet 4 days prior to and during each study day. Bronchial provocation tests were conducted in the morning and afternoon of the three separate study days--control and two medication days--using a standardised technique. On the control day, the dose of carbachol required to reduce the partial expiratory flow volume at 25% of vital capacity (V25p) by at least 25% was established. A significant protective effect was achieved with both TH (p less than 0.05) and NB (p less than 0.001) as measured by V25p. Bronchoprotection was achieved with low maintenance serum levels of TH.


Assuntos
Aminofilina/análogos & derivados , Espasmo Brônquico/tratamento farmacológico , Difilina/uso terapêutico , Teofilina/análogos & derivados , Teofilina/uso terapêutico , Adulto , Aminofilina/sangue , Aminofilina/farmacocinética , Aminofilina/uso terapêutico , Testes de Provocação Brônquica , Espasmo Brônquico/induzido quimicamente , Espasmo Brônquico/fisiopatologia , Carbacol , Ensaios Clínicos como Assunto , Método Duplo-Cego , Combinação de Medicamentos/sangue , Combinação de Medicamentos/farmacocinética , Combinação de Medicamentos/uso terapêutico , Difilina/sangue , Difilina/farmacocinética , Feminino , Humanos , Masculino , Distribuição Aleatória , Testes de Função Respiratória , Teofilina/sangue , Teofilina/farmacocinética , Equivalência Terapêutica
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