RESUMO
AIM: To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients. MATERIAL AND METHODS: Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1). RESULTS: Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function. Such patients had a low concentration of serum IL-1beta receptors antagonists. Severity of proteinurea correlated with serum level of TNF-alpha. If the latter was higher than 120 pg/ml, there was a high probability of CRF development within 2 years. CONCLUSION: Pathogenesis of CRF in CGN is associated with proinflammatory cytokines, especially TNF-alpha. Its serum concentration can be used for evaluating risk of renal function deterioration.
Assuntos
Glomerulonefrite/complicações , Glomerulonefrite/imunologia , Interleucina-1/sangue , Interleucina-1/imunologia , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Fator de Necrose Tumoral alfa/imunologia , Fator de Necrose Tumoral alfa/metabolismo , Adolescente , Adulto , Doença Crônica , Progressão da Doença , Feminino , Humanos , Hipertensão Renal/complicações , Masculino , Pessoa de Meia-Idade , Proteinúria/etiologia , Proteinúria/urinaRESUMO
The authors justify necessity to improve system of clinical examination of workers, within "Health" priority national project, present suggestions on realization of specific measures in metallurgic enterprises.
Assuntos
Programas de Rastreamento/métodos , Programas de Rastreamento/normas , Metalurgia , Doenças Profissionais/epidemiologia , Serviços de Saúde do Trabalhador/organização & administração , Adulto , Prioridades em Saúde , Humanos , Doenças Profissionais/diagnóstico , Garantia da Qualidade dos Cuidados de Saúde , Federação Russa/epidemiologiaRESUMO
Hemosorption and plasmapheresis were studied for effects on lipid peroxidation, antioxidant blood activity, platelet hemostasis, microcirculation, myocardial contractility and intracardiac hemodynamics. The results demonstrated that antioxidant blood response is a key criterion responsible for decreased efficacy of hemosorption and plasmapheresis in patients with progressive angina pectoris with chronic heart failure. The results of hemosorption and plasmapheresis in the above patients may become better if an adjuvant antioxidant therapy is used.
