1.
J Med Chem
; 30(1): 198-200, 1987 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3027333
RESUMO
Acyclic neplanocin analogues were prepared by condensation of adenine or N2-acetylguanine with (E)-1,4-dichlorobut-2-ene and subsequent hydrolysis. The N-9-substituted product 9-[(E)-4-hydroxybut-2-enyl]adenine was obtained when adenine was employed as the starting purine, while N2-acetylguanine yielded both the N-7 and N-9 isomers. Cell-culture studies revealed that only the chloro-substituted intermediate 9-[(E)-4-chlorobut-2-enyl]adenine exhibited significant cytotoxicity against P-388 mouse lymphoid leukemia cells, while the N-9-substituted guanine analogue 9-[(E)-4-hydroxybut-2-enyl]guanine inhibited replication of herpes simplex viruses type 1 and type 2.
Assuntos
Adenina/análogos & derivados , Antineoplásicos/síntese química , Antivirais/síntese química , Guanina/análogos & derivados , Adenina/síntese química , Adenina/farmacologia , Adenina/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Guanina/síntese química , Guanina/farmacologia , Guanina/uso terapêutico , Indicadores e Reagentes , Leucemia P388/tratamento farmacológico , Espectroscopia de Ressonância Magnética , Camundongos , Simplexvirus/efeitos dos fármacos , Espectrofotometria Infravermelho , Relação Estrutura-Atividade
2.
Arch Biochem Biophys
; 204(1): 234-40, 1980 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7000006