DYNAMICS OF CHANGES OF C-REACTIVE PROTEIN LEVEL IN BLOOD SERUM IN THE DEVELOPMENT AND COURSE OF EXPERIMENTAL PERIODONTITIS AND THEIR CORRECTION BY FLAVONOL.

OBJECTIVE: The aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin. PATIENTS AND METHODS: Materials and methods: Modeling of periodontitis was performed by the following method: after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.01 ml of egg protein with cultures of Streptococcus hemolytic and Staphylococcus aureus at a dose of 4 CFU was performed in the area of periodontal tissues of the lower incisor as an initiating inflammatory factor. To enhance the immune process, a complete Freund's adjuvant was introduced into the animal's hind limb at the same time. RESULTS: Results: Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the experiment without the use of flavonol. When comparing this indicator on the 14th day of development of experimental periodontitis with correction, it was found that it remained slightly higher than the indicators of the intact group of rats. CONCLUSION: Conclusions: The level of C-reactive protein in the blood serum of experimental animals is an important indicator of the immune-inflammatory response, which increases its activation of the inflammatory system. The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.

Comparative assessment of the state of bone resorption in patients with chronic generalized periodontitis according to orthopantomogram and cone-beam computed tomography.

AIM: The aim of the study was to assess bone resorption in patients with chronic generalized periodontitis according to orthopantomogram (OP) and cone-beam computed tomography (CBCT) and substantiate which of these methods is the most appropriate for use. MATERIALS AND METHODS: In order to compare the objectivity of the results of examining the periodontal bone tissue by the above methods (panoramic radiography and computed tomography), we analyzed 26 panoramic radiographs and computed tomograms of the same patients, performed on a PICASSO (3D) computed tomograph by «Vatech¼. RESULTS: Comparison of CBCT and OP data in patients with periodontal tissue disease showed a significant difference between the indicators of bone tissue resorption in the mesiodistal direction, and revealed that the volumetric image is significantly objective X-ray picture in periodontal diseases by identifying the state (resorption) of the vestibular and oral cortical plates in any section dentition. At the same time, only according to CBCT data, an objective assessment of bone resorption in the vestibulo-oral direction is likely. CONCLUSIONS: Mesiodistal CT and orthopantomographic data do not match well enough. They allow with high accuracy to identify areas of resorption only from the medial and distal sides. However, the vestibulooral CT projection indicates the bias of a two-dimensional image for obtaining an accurate X-ray picture of the state of the alveolar bone and a complete assessment of bone resorption.