RESUMO
AIM: To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men. MATERIALS AND METHODS: 85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils. RESULTS AND DISCUSSION: Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium. CONCLUSION: Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.
Assuntos
Neutrófilos/metabolismo , Obesidade , Disfunção Ventricular Esquerda , Remodelação Ventricular , Adulto , Insuficiência Cardíaca Diastólica/etiologia , Insuficiência Cardíaca Diastólica/metabolismo , Insuficiência Cardíaca Diastólica/fisiopatologia , Humanos , Hipertrofia Ventricular Esquerda/etiologia , Hipertrofia Ventricular Esquerda/metabolismo , Hipertrofia Ventricular Esquerda/fisiopatologia , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/metabolismo , Obesidade/fisiopatologia , Estresse Oxidativo , Índice de Gravidade de Doença , Estatística como Assunto , Disfunção Ventricular Esquerda/etiologia , Disfunção Ventricular Esquerda/metabolismo , Disfunção Ventricular Esquerda/fisiopatologiaRESUMO
Treatment of rat hepatocyte plasma membranes with five novel synthetic heteroprostanoids of A- and E-types significantly decreased basal activity of adenylyl cyclase. Inhibition of forskolin-stimulated activity of the enzyme was seen as well. The maximal effective concentration for all substances tested was found at approximately 5x10(-6)-1x10(-5) M. The values of half maximal concentration (IC50) for all prostanoids were at the region of 0.7-1.1 microM. Prostanoids belonging to cyclopentenone group A (U-39, U-26) were less active than analogs of 11-deoxy-PGE1 (TA-227, TA-280, and TA-239). The strongest inhibitory effect of adenylyl cyclase activity (more than 3 times) was determined in the presence of prostanoid TA-227 possessing hydrophobic 15-phenyl ring and isoxazol group in omega-chain. The investigation of AC activity in the presence of different concentrations of prostanoids and varying concentrations of Mg x ATP has demonstrated that a non-comprehensive mechanism with particular effect takes place in case of AC inhibition by the heteroprostanoids.
Assuntos
Inibidores de Adenilil Ciclases , Inibidores Enzimáticos/farmacologia , Hepatócitos/enzimologia , Prostaglandinas/química , Adenilil Ciclases/metabolismo , Alprostadil/análogos & derivados , Alprostadil/metabolismo , Animais , Membrana Celular/metabolismo , Colforsina/metabolismo , AMP Cíclico/metabolismo , Relação Dose-Resposta a Droga , Hepatócitos/efeitos dos fármacos , Hepatócitos/metabolismo , Concentração Inibidora 50 , Masculino , Modelos Químicos , Prostaglandinas/metabolismo , Ratos , Ratos WistarRESUMO
Discusses the methodological problems of forensic psychiatric evaluations of mental disorders in the structure of the most incident endogenous psychosis, schizophrenia, under conditions of expert evaluation in a civil process. Presents criteria permitting the differentiation between pathological states.
Assuntos
Competência Mental/legislação & jurisprudência , Psicologia do Esquizofrênico , Direitos Civis/legislação & jurisprudência , Psiquiatria Legal/legislação & jurisprudência , Humanos , Competência Mental/psicologia , Psicopatologia , Federação RussaAssuntos
Alcoolismo/diagnóstico , Crime , Alcoolismo/etiologia , Alcoolismo/psicologia , Feminino , Humanos , Psicopatologia , Psicologia do Esquizofrênico , Transtorno da Personalidade Esquizotípica/complicações , Transtorno da Personalidade Esquizotípica/diagnóstico , Transtorno da Personalidade Esquizotípica/psicologia , U.R.S.S.Assuntos
Oftalmopatias/cirurgia , Cirurgia Plástica/métodos , Adulto , Seguimentos , Humanos , Pessoa de Meia-IdadeRESUMO
Described and figured are deutonymphs of 18 species of the genus Hirstionyssus Fonseca, 1948, parasites of small mammals (H. carnifex (L. C. Koch) Oudemans, 1913; H. blanchardi (Trouessart, 1904); H. ellobii Bregetova, 1956; H. myospalacis Zemskaja et Piontkovskaja, 1957; H. transiliensis Bregetova, 1956; H. georgicus Bregetova, 1956; H. sciurinus (Hirst, 1921); H. confucianus (Hirst, 1921); H. bregetovae Razumova, 1953; H. macedonicus (Hirst, 1921); H. pauli Willmann, 1952; H. criceti (Sulzer, 1774); H. latiscutatus (Meillon et Lavoipierre, 1944); H. apodemi Zuevsky, 1970; H. pavlovskii Zemskaja, 1959; H. soricis (Turk, 1945); H. meridianus Zemskaja, 1955; H. isabellinus Oudemans, 1913); Keys to deutonymphs of the genus Hirstionyssus are given for the first time.
