[Effect of non-steroid anti-inflammatory and glucocorticoid agents on development of gastrointestinal lesions in patients with rheumatic diseases]. / Vliianie nesteroidnykh protivovospalitel'nykh i gliukokortikoidnykh preparatov na razvitie porazhenii pishchevaritel'nogo kanala u bol'nykh s revmatologicheskimi zabolevaniiami.

A comparative evaluation was done of frequency and severity of upper gastrointestinal mucosal lesions in patients taking nonsteroid antiinflammatory drugs (NSAID) and glucocorticosteroids (GCS). A total of 65 rheumatic patients examined endoscopically entered the study. The patients were divided into three groups. Group I comprised 12 patients placed on GCS only, group II was 35 patients on NSAID, group III was 18 patients who received NSAID plus GCS. Gastropathies were diagnosed in 25%, 45.7%, 44.4% of patients in groups I, II, and III respectively. Group II patients had a higher incidence of serious afflictions. As far as the gastrointestinal mucosa is concerned, GCS have been shown to be superior to NSAID. A combined use of NSAID + GCS, unlike NSAID alone, has not been found to increase the risk of development of gastropathy.

[Biological age, adrenoreception and lipid peroxidation in patients with ischemic heart disease]. / Biologicheskii vozrast, adrenoretseptsiia i perekisnoe okislenie lipidov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.