RESUMO
Chloroquine diphosphate, a highly water-soluble drug, was encapsulated by using a non-solvent addition coarcevation method. The coating material employed was Eudragit RS100. The liquid manufacturing vehicle was tetrahydrofuran (THF) while the non-solvent liquid was cyclohexane. Polyisobutylene (PIB) was used as an anti-aggregating agent. Particle size as well as shape evaluation was performed. Total drug content, in vitro drug release (from the microcapsules) as well as tasting test experiments were performed. The release studies on the microcapsules revealed an in vitro prolonged release effect while at the same time the bitter taste of the drug appeared to have been considerably masked by this method.
Assuntos
Resinas Acrílicas/metabolismo , Cloroquina/análogos & derivados , Composição de Medicamentos , Administração Oral , Antimaláricos/metabolismo , Cápsulas/administração & dosagem , Cápsulas/química , Cápsulas/metabolismo , Cloroquina/metabolismo , Cicloexanos/metabolismo , Composição de Medicamentos/métodos , Furanos/metabolismo , Microscopia Eletrônica de Varredura , Polienos/farmacologia , Polímeros/farmacologia , PaladarRESUMO
A new drug delivery system with controlled-release effect based on press-coated tablets using poly-D(-)-3-hydroxybutyric acid (Poly-HB) is presented. Model investigations show that the coating of a drug containing core with an indifferent matrix consisting of Poly-HB, a channeling agent (sodium chloride, potassium nitrate or lactose) and the initial dose of the drug leads to a zero-order release kinetics. The system is applicable for oral and parenteral dosage of various drugs.
