[Early and late results of radiation and combined modality therapy of hemangiomas of the spine]. / Blizhaishie i otdalennye resul'taty luchevoi i kompleksnoi terapii gemangiom pozvonochnika.

The authors described the results of therapy of 74 spinal hemangioma patients. The patients were divided into 2 groups: 1--radiotherapy only; 2--radiotherapy following surgical intervention for enhanced symptoms of spinal compression. Gamma-beam therapy was given 5 times a week at a single dose of 0.8-1.2 Gy. A total dose delivered to the cervical spine was 26-32 Gy, to the thoracic spine--28-30 Gy, to the lumbar spine--30-34 Gy. Field sizes varied from 3 X 4 to 3 X 12 cm depending on lesion spreading. Therapy also included traction on a special platform bed. An analysis of long-term therapeutic results (from 3 to 13 yrs.) has shown that clinical convalescence with regained working capacity in the 1st group (40 patients) was observed in 21 patients, in the 2nd group (34 patients)--in 5 patients only. Partial functional restoration was observed in both groups (19 patients in each group). The therapy applied was ineffective in 10 patients of the 2nd group.

[Results of radiation and combination therapy of glomus tumors]. / Rezul'taty luchevoi i kombinirovannoi terapii glomusnykh opukholei.

Over the period of 1965-1985 radiation and combined therapy for glomus tumors of different sites was provided to 80 patients aged 34 to 79. Radiation therapy alone was given to 51 patients, of them 18 patients had recurrences of malignant tumors. Radiation therapy following surgery was given to 29 patients. Gamma-beam therapy was given from fields, size from 5 X 5 to 8 X 10 cm, using in some cases lattice and wedge-shaped filters, at a single dose of 2-3 Gy up to a total dose of 60-70 Gy. Of 33 patients with primary malignant tumors 30 lived over 5 yrs., of 18 patients with postoperative recurrences 15 lived for 5 yrs. Of 29 patients who had been on combined therapy, 2 died in 3-5 yrs. of causes unrelated to the main disease.

[Radiation and combination therapy of malignant tumors of the vulva]. / Luchevaia i kompleksnaia terapiia zlokachestvennykh opukholei vul'vy.

The paper is concerned with the results of radiation and multimodality (chemo- and radiotherapy) therapy of patients with malignant vulval tumors. All 112 patients had Stage III-IV disease. A single focal dose was 1.8-2.5 Gy, a summary dose varied from 65 to 100 Gy depending on growth type, tumor histological structure and other factors. Cyclophosphamide, thiotepa, methotrexate and 5-FU were used during simultaneous chemotherapy. Single and summary doses were administered according to an individual program. Drugs reducing local and general radiation reactions were widely used. A direct clinical cure and partial resorption were noted in 109 patients, no effect in 3. The use of various methods of gamma-beam therapy and chemoradiotherapy resulted in the 3-year survival in 51% and the 5-year survival in 18.7% of the patients.

[Nature of the stimulating substances found in the vital activity products of yeastlike fungi]. / Priroda stimuliruiushchikh veshchestv, soderzhashchikhsia v produktakh zhiznedeiatel'nosti drozhzhepodobnykh gribov.

The cultural broth of Candida tropicalis was shown to contain an active compound which stimulated the synthesis of levorin, a polyene antibiotic Succinic acid was found to stimulate the antibiotic synthesis. The stimulating effect of the active compound increased in proportion to the content of succinic acid in it and became maximal at the same concentration of succinic acid as in a pure preparation. However, succinic acid was not an only compound responsible for the elevated synthesis of the antibiotic since the biostimulating effect was higher than that of pure succinic acid.

[Radiation therapy of malignant eyelid tumors]. / Luchevaia terapiia zlokachestvennykh opukholei vek.

The authors presented the short- and long-term results of brachytherapy and combined radiotherapy in 348 patients with malignant eyelid neoplasms localized in the lower eyelid in 187 patients, in the upper eyelid in 99, in both eyelids in 4, in the inner angle of the eye in 39 and in the outer angle of the eye in 10 patients. A single focal dose was 1.5-2.5 Gy, a total dose 45-80 Gy with relation to tumor prevalence and histological structure. The eyeball was protected with the help of a lead lens ("eye prosthesis") and a universal tungsten membrane. The devices ensured nearly 100% protection of the eyelid against ionizing radiation. Direct clinical cure was noted in 342 patients, partial tumor resorption in 6 patients. Three-year recurrence-free survival was noted in 330 patients (94.8%), five-year survival in 319 (92.8%).

[Radiation therapy of malignant neoplasms of the middle ear after nonradical surgical interventions]. / Luchevaia terapiia zlokachestvennykh novoobrazovanii srednego ukha posle neradikal'nykh khirurgicheskikh vmeshatel'stv.

The paper is concerned with the short- and long-term results of gamma-beam therapy and chemo- and radiotherapy in 109 patients with malignant middle ear tumors after nonradical surgical interventions. A single focal dose was 2-2.5 Gy, a summary dose varied within 60-80 Gy with relation to the degree of dissemination, growth type and tumor histological structure. A 3-year survival rate was 41.1%, a 5-year survival rate was 21%.

[Radiation and chemoradiation therapy of malignant laryngopharyngeal tumors]. / Luchevaia i khimioluchevaia terapiia zlokachestvennykh opukholei gortanoglotki.

The paper is concerned with the results of open field gamma-beam therapy using grid filters. A group of patients with Stage III-IV tumors received chemoradiotherapy. A single focal radiotherapeutic dose varied from 1.6 to 2.5 Gy, a summary dose from 55 to 70 Gy depending on tumor stage and histological structure. A chemotherapeutic drug was prescribed within the limits of 1/2-2/3 of a standard dose. Intensive substitution and blood-stimulating therapy was provided. With the use of different radiotherapeutic and chemoradiotherapeutic methods the 3- and 5-year survival rates were 19.8% and 14.3%, respectively.

[Results of radio- and chemoradiotherapy of malignant nasopharyngeal neoplasms]. / Rezul'taty luchevoi i khimioluchevoi terapii zlokachestvennykh novoobrazovanii nosoglotki.

The paper is concerned with the results of open field gamma-beam therapy and gamma-therapy using gamma-beam forming agents. Besides, a method of simultaneous chemo- and radiotherapy was used for 175 nasopharyngeal cancer patients. Of them 2 had Stage II tumors, 22 Stage III tumors, 151 (first admitted for treatment as well as those with recurrences and tumor metastases), by local spread and regional and distant metastatic spread, had Stage IV tumors. A single focal dose was 1.4-2.5 Gy, the summary dose 55-70 Gy. In simultaneous chemo- and radiotherapy using gamma-beam forming agents the values of a single and the summary focal dose did not lessen; a single and the summary dose of chemotherapeutic drugs got less and equaled 1/2-2/3 of standard dosages. The chemotherapeutic component of multimodality chemotherapy was indicated with regard to a tumor histological structure. The best results were achieved in the group of patients on multimodality chemo- and radiotherapy. Of 75 patients, a complete or partial tumor resorption was noted in 71. With the use of all the methods of radio- and multimodality therapy the 3-year survival was 41.1%, the 5-year survival 19.4% (34 patients out of the 175).

[Radiotherapy and chemoradiotherapy of neglected forms of malignant oropharyngeal tumors]. / Luchevaia i khimioluchevaia terapiia zapushchennykh form zlokachestvennykh novoobrazovanii rotoglotki.

Open-field gamma-beam therapy using grid filters was used for 53 patients with Stage III-III stomatopharyngeal tumors. Besides, to compare therapeutic efficacy the 2nd group was taken (52 persons with Stage III-IV) where chemotherapy was used simultaneously. Single and summary radiation doses did not lower. A chemotherapeutic agent dose was equal to 1/2 up to 2/3 of the standard one. Powerful substitution and hemostimulation therapy and a great variety of drugs were employed not to induce deep changes of hemopoiesis and immunosuppression. A single focal dose in gamma-beam therapy varied from 1.6 to 2.5 Gy, the summary dose from 55 to 70 Gy depending on the stage of disease and the histological structure of a tumor. The prescription of one or another chemotherapeutic agent was mainly determined by the morphological structure of a tumor.

[Importance of direct roentgeno-radioisotope lymphography in the diagnosis of lymphogenic metastasis]. / Znachenie priamoi rentgenoradioizotopnoi limfografii v diagnostike limfogennykh metastazov.

Using the results of direct x-ray-radionuclide lymphography in 119 patients with malignant tumors of different sites lymphogenic metastases were diagnosed in 68% of the cases as compared to 52% with the use of radiopaque direct lymphography only and 36.5% of the cases detected on clinical examination. This method made it possible to change in 44 out of 119 patients a stage of the disease to a more advanced one.