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1.
Pol Przegl Chir ; 95(4): 1-5, 2023 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-36808049

RESUMO

OBJECTIVES: Most authors highlight the absence of international guidelines in the treatment of recurrent rectal prolapse (RRP), even among coloproctologists. However, it is clearly indicated that Delormes or Thierschs surgeries are reserved for older and fragile patients, so on the other hand, transabdominal surgeries are dedicated to generally fitter patients. The aim of the study is evaluation of surgical treatment effects for recurrent rectal prolapse (RRP)Methods: The study group comprised of 20 female and 2 male patients aged from 37 to 92 years (subjected to treatment last 20 years). Initial treatment consisted of abdominal mesh rectopexy (n=4), perineal sigmorectal resection (n=9), Delormes technique (n=3), Thierschs anal banding (n=3), colpoperineoplasty (n=2), anterior sigmorectal resection (n=1). The relapses occured between 2 to 30 months. RESULTS: Reoperations consisted of abdominal without (n=8) or with resection rectopexy (n=3), perineal sigmorectal resection (n=5), Delormes technique (n=1), total pelvic floor repair (n=4), perineoplasty (n=1). 11 patients (50%) were completely cured. 6 patients developed subsequent RRP. They were successfully reoperated (2 rectopexies, 2 perineocolporectopexies, 2 perineal sigmorectal resections). CONCLUSIONS: Abdominal mesh rectopexy is the most effective method for RP and RRP treatment. Total pelvic floor repair may prevent RRP. Perineal rectosigmoid resection results of less permament effects of RRP repair.


Assuntos
Proctocolectomia Restauradora , Prolapso Retal , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Prolapso Retal/cirurgia , Estudos Retrospectivos , Reto/cirurgia , Abdome/cirurgia , Resultado do Tratamento , Telas Cirúrgicas
2.
Pol Przegl Chir ; 95(3): 1-5, 2022 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-36805988

RESUMO

Rekomendacje dotycz etiologii i klasyfikacji przetok odbytniczo-pochwowych a przede wszystkim zasad postpowania chirurgicznego. W leczeniu przetok zlokalizowanych w dolnej czci odbytnicy zastosowanie znajduj techniki wycicia kanau przetoki i warstwowego zamykania powstaego ubytku, w tym rwnie z rekonstrukcj aparatu zwieraczowego odbytu. Dla wzmocnienia rekonstruowanych tkanek stosuje si matryc kolagenowo-fibrynow TachosilR. W przypadku wysokich przetok odbytniczo-pochwowych wykonuje si usunicie zmienionego chorobowo odcinka jelita wraz z ujciem przetoki z jednoczasowym lub odroczonym odtworzeniem cigoci przewodu pokarmowego.


Assuntos
Fístula Vaginal , Feminino , Humanos
3.
Pol Przegl Chir ; 95(3): 1-5, 2022 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-36805991

RESUMO

Zaburzenia czynnociowe dna miednicy s zjawiskiem zoonym zalenym od ubytkw anatomicznych w ukadzie powiziowo-miniowym oraz od stanu ich unerwienia i jakoci tkanki cznej. Maj one rozmaite postacie i lokalizacje. Od ich konfiguracji zaley obraz kliniczny zaburze czynnociowych w tym obnianie dna miednicy, wypadanie narzdu rodnego, odbytnicy, rectocele, enterocele i cystocele. Rekomendacje dotycz zasad diagnostycznych oraz kompleksowego postepowania terapeutycznego. Istot leczenia chirurgicznego jest odbudowa architektoniki tkanek oporowych dna miednicy technikami beznapiciowymi z uyciem materiaw protetycznych. Umoliwia to przeprowadzenie skutecznego umocowania obniajcych si struktur i wypadajcych narzdw.


Assuntos
Diafragma da Pelve , Sociedades Científicas , Humanos , Polônia , Retocele , DNA
4.
Pol Przegl Chir ; 95(3): 1-5, 2022 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-36805996

RESUMO

Zwenie odbytu jest rzadkim powikaniem w proktologii. Rekomendacje dotycz wskaza i sposobw leczenia zachowawczego i zabiegowego. Techniki chirurgiczne zale od stopnia zwenia, jego rozmiarw i lokalizacji. Najczciej stosuje si wycicie tkanek bliznowatych i plastyk z uyciem przesunitych patw skrnych Y-V lub patw rotacyjnych. Zwenia krytyczne, nie poddajce si rekonstrukcji chirurgicznej mog wymaga zaoenia odbarczajcej przetoki jelitowej.


Assuntos
Sociedades Científicas , Humanos , Constrição Patológica , Polônia
5.
Case Rep Surg ; 2021: 6615612, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33763281

RESUMO

A pancreaticopleural fistula is a rare cause of pleural effusion. It is a complication of chronic or acute pancreatitis. It is rarely formed to the right or both pleural cavities. Diagnosis and proper treatment often turn out to be difficult and require the cooperation of a multidisciplinary team. The authors present the case of a 59-year-old patient treated for recurrent pleural effusion of unknown origin, first to the left and then to the right pleural cavity. After many months of treatment, the diagnosis of a pancreaticopleural fistula was made. The patient underwent surgery, which finally led to a successful complete recovery. Pancreaticopleural fistula should always be considered in patients with pleural effusion of unknown origin.

6.
Pol Przegl Chir ; 92(4): 58-62, 2019 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-32908017

RESUMO

Aim An ileal pouch anal anastomosis (IPAA) leak is one of the most severe complication after restorative proctocoletomy (RPC). We present a rare case of a successful management of IPAA leak after RPC without defunctionig stoma with the utility of endoscopic vacuum therapy. Methods A 57-year-old male with a ileal pouch anal anastomosis leak after RPC due to ulcerative colitis with presacral abscess was qualified for endoscopic vacuum therapy (EVT). The abscess of the left buttock was drained and secured with suction drain (redon drain). Due to the lack of defunctioning stoma, a system for contain and divert fecal matter was placed within afferent limb of the J-pouch and EVT was placed directly within IPAA dehiscence. EVT was changed every third day. Results The patient underwent a total of five EVT sessions. Improvement of patient's general condition characterized with lack of pelvic pain, fever and reduction of inflammatory markers was achieved. Locally, anastomosis dehiscence was healed with prominent reduction in the defect's dimension, contraction and revascularization. Based on imaging studies no chronic presacral sinus or any other perianal disturbances were revealed at the time of five months follow up. Conclusions EVT is a promising method for management of IPAA leak. Although, it remains extremely difficult, EVT may serve as a method of choice in early pouch-related septic complications after RPC performed without defunctioning stoma.


Assuntos
Colite Ulcerativa/cirurgia , Bolsas Cólicas , Tratamento de Ferimentos com Pressão Negativa/métodos , Proctocolectomia Restauradora/efeitos adversos , Estomas Cirúrgicos , Anastomose Cirúrgica/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/cirurgia , Proctocolectomia Restauradora/métodos
7.
Ann Agric Environ Med ; 23(4): 692-695, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-28030945

RESUMO

INTRODUCTION: A rectocele is a hernation of the rectum into the vaginal lumen developing as a consequence of weakness of the rectovaginal septum. It affects about 18% of women after childbearing age. Symptoms associated with a rectocele include constipation, vaginal fullness or heaviness, feeling of a bulging mass within vagina, incomplete stool evacuation and dyspareunia. Current methods of surgical treatment of a rectocele often require implantation of a mesh graft. In most of cases, synthetic and non-absorbable meshes are used. Although implantation of a synthetic and non-absorbable mesh is effective in the treatment of rectocele, a high rate of mesh erosion has been reported. CASE REPORT: This study presents a surgical technique and case report for the treatment of a rectocele in a 46-year-old women by implantation of a porcine-derived absorbable collagen mesh (Pelvicol®) by transvaginal approach, with six year follow-up. A review of the literature concerning implantation of Pelvicol® for the treatment of rectocele was also undertaken. CONCLUSIONS: The clinical experience and review of the literature by the authors suggest that a porcine-derived acellular mesh is non-cytotoxic, pyrogenic or allergenic, and the application of a biomesh in the management of rectocele is effective and safe, and the risk of mesh erosion is very low.


Assuntos
Colágeno/uso terapêutico , Retocele/cirurgia , Telas Cirúrgicas , Vagina/cirurgia , Doenças Vaginais/cirurgia , Animais , Feminino , Humanos , Pessoa de Meia-Idade , Suínos , Resultado do Tratamento
8.
Ginekol Pol ; 87(11): 729-732, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27958629

RESUMO

OBJECTIVES: This report describes results of posterior vaginal wall prolapse and rectocele treatment performing tension free reconstruction method with polypropylene mesh implantation. MATERIAL AND METHODS: In years 2001 to 20015, 71 female patients in age of 42-82 years were surgically treated. Besides difficult emptying they complained of feeling of heaviness in the pelvis (38%) and dyspareunia (16.9%). Defecography and magnetic resonance proved the presence of rectocele in 84.5%, enterocele in 38%, descending perineum in 28.2%, genital organ prolapse in 23.9%, and rectal prolapse in 22.5% cases. 37 patients with defects of low location have undergone implantation of prosthetic material from vaginal approach. In cases of high location and genital organ prolapse abdominal approach was done. RESULTS: Permanent reconstruction of the rectovaginal septum has been achieved in 70 patients (98%). Symptoms of dyschesia, pelvic plain, heavy straining were persisted in 4 patients (10.3%). 3 cases of mash erosions were diagnosed. One patient was reoperated. Among 6 other patients who needed futher surgical treatment only one was reoperated because of vaginal prolapse. 81.7% of patients was satisfied with their treatment. CONCLUSION: Using prosthetic materials in pelvic floor defects treatment is characterized by high efficacy and low complication percentage.


Assuntos
Retocele/cirurgia , Telas Cirúrgicas , Prolapso Uterino/cirurgia , Adulto , Idoso , Dispareunia/etiologia , Feminino , Procedimentos Cirúrgicos em Ginecologia/métodos , Humanos , Pessoa de Meia-Idade , Diafragma da Pelve/cirurgia , Períneo/cirurgia , Polipropilenos , Estudos Retrospectivos , Resultado do Tratamento , Prolapso Uterino/complicações
9.
Prz Gastroenterol ; 11(4): 232-238, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28053677

RESUMO

INTRODUCTION: Monitoring the response to biological treatment in Crohn's disease (CD) is a very important element of the therapeutic optimisation. AIM: To evaluate the usefulness of measuring calprotectin, lactoferrin, and myeloperoxidase in stool as markers of long-term clinical and endoscopic response to anti-tumour necrosis factor α (anti-TNF) treatment in CD. MATERIAL AND METHODS: The studied group consisted of 35 CD patients treated with anti-TNF-α antibodies. Clinical activity was evaluated using Crohn's Disease Activity Index (CDAI), and the exacerbation of endoscopic changes was evaluated using a Simple Endoscopic Score for Crohn's Disease (SES-CD). The concentration of calprotectin, lactoferrin, and myeloperoxidase was measured using the ELISA method. All measurements were performed three times - before, after 3 months, and after a year of therapy. RESULTS: During anti-TNF treatment the concentrations of all measured faecal markers decreased significantly in relation to baseline values. We observed a significant correlation at all time-points: before the therapy, after 3 months, and 12 months after starting the therapy, between the concentration of calprotectin and SES-CD, calprotectin and CDAI, as well as between lactoferrin and SES-CD, and lactoferrin and CDAI. Myeloperoxidase correlated with both SES-CD and CDAI only after 1 year of treatment. CONCLUSIONS: Faecal calprotectin and lactoferrin are valuable markers of clinical and endoscopic activity of CD in patients treated with anti-TNF antibodies. They are useful in monitoring the response to treatment. The usefulness of myeloperoxidase in this respect remains controversial.

10.
Ginekol Pol ; 86(6): 429-33, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26255450

RESUMO

OBJECTIVES: Anatomical and functional results of a modified sacral perineocolporectopexy for extreme forms of complex pelvic organs prolapse. MATERIAL AND METHODS: Between 2005 and 2010, 10 women aged 47-75 years were treated by abdomino-perineal implantation of polypropylene mesh for modified sacral perineocolporectopexy and subsequently followed-up. They were suffering from enterocele (9 pts), genital prolapse (8 pts), descending perineum (5 pts), rectal prolapse (4 pts), rectocele (3 pts). Five women were incontinent (mean Wexner: 9) and six had incomplete rectal evacuation. Defecography revealed enterocele III°(5 pts) and II°(4 pts). MR designed descending perineum in 5 pts (mean: 3.8 cm). RESULTS: Permanent reconstruction of the pelvic floor and remission of organs prolapse was achieved at 12-months follow-up in all except 1 patient. There were 2 small vaginal erosions of the mesh and 1 haematoma within the pelvic floor Improvement at rectal emptying was found in 4 patients, feeling of pelvic heaviness in 6 patients, dyspareunia in 3 patients. Mean incontinence score decreased from 9 to 4. CONCLUSIONS: 1. Modified sacral perineocolporectopexy is effective in the treatment of complex pelvic floor anatomical defects and organ prolapse. 2. Improvements in rectal emptying, pelvic feeling of heaviness and dyspareunia have been achieved. 3. The implant tolerance was good and the complications rate was law.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/métodos , Prolapso de Órgão Pélvico/cirurgia , Telas Cirúrgicas , Técnicas de Sutura , Idoso , Idoso de 80 Anos ou mais , Colposcopia/métodos , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Saúde da Mulher
11.
BMC Surg ; 15: 41, 2015 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-25885184

RESUMO

BACKGROUND: Giant condyloma acuminatum or Buschke - Loewenstein tumor is a very rare disease usually located in the genital, anorectal, and perianal regions. It is locally invasive but in mostly cases displays a benign cytology on preoperative tissue sampling. Because of its low incidence little is known about treatment outcomes. Complete surgical excision is the treatment of choice. Different surgical methods have been applied to reach curability. To our knowledge such an advanced sized tumors in this localization has only been reported few times before with different surgical techniques being applied. CASE PRESENTATION: We describe a case of 56 years old female with 20 years persisting condyloma acuminatum progressing to a very huge dimensions perianal Buschke-Lowenstein tumor with one of the widest excision in the literature without the need for diverting stoma. The tumor size and its location determined the choice of treatment option and suspected prognosis for the patient outcome. Treatment was impeded by patient's malnutrition. The giant Buschke - Loewenstein tumor was resected from the anus, perineum and gluteal areas. The large tissue losses were simultaneously covered with rotational skin and fatty subcutaneous tissue flaps, mobilized from neighboring gluteal and femoral areas. The circumferential part of the anal canal was covered with skin grafted from the mentioned flaps and it was attached to the anal mucosa. No protective stoma was formed. Despite temporary problems with healing of the covering skin flaps, full permanent coverage of the resection site has been achieved. Anal canal function has also improved within the time. CONCLUSION: The patient with BLT must be very carefully clinical and imagistic investigated in order to detect the tumor visceral invasion and to establish the extension of the surgical procedure. There exists an extensive and time-consuming surgical procedure which allows to remove the giant anorectal Buschke - Loewenstein tumors with good function of the anorectum and without the necessity of diverting stoma creation.


Assuntos
Neoplasias do Ânus/patologia , Neoplasias do Ânus/cirurgia , Tumor de Buschke-Lowenstein/patologia , Tumor de Buschke-Lowenstein/cirurgia , Procedimentos de Cirurgia Plástica , Feminino , Humanos , Pessoa de Meia-Idade , Períneo/patologia , Retalhos Cirúrgicos , Resultado do Tratamento
12.
Pol Przegl Chir ; 86(12): 576-83, 2015 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-25803057

RESUMO

UNLABELLED: Iatrogenic bile duct injuries (BDI) are still a challenging diagnostic and therapeutic problem. With the introduction of the laparoscopic technique for the treatment of cholecystolithiasis, the incidence of iatrogenic BDI increased. The aim of the study was a retrospective analysis of 69 patients treated at the department due to iatrogenic BDI in the years 2004-2014. MATERIAL AND METHODS: In this paper, we presented the results of a retrospective analysis of 69 patients treated at the Department due to iatrogenic BDI in the years 2004-2014. The data were analysed in terms of age, sex, type of biliary injury, clinical symptoms, the type of repair surgery, the time between the primary surgery and the BDI management, postoperative complications and duration of hospital stay. RESULTS: 82.6% of BDI occurred during laparoscopic cholecystectomy, 8.7% occurred during open cholecystectomy, whereas 6 cases of BDI resulted from surgeries conducted for other indications. In order to assess the degree of BDI, Bismuth and Neuhaus classifications were used (for open and laparoscopic cholecystectomy respectively). 84.1% of patients with confirmed BDI, were transferred to the Department from other hospitals. The average time between the primary surgery and reoperation was 6.2 days (SD 4). The most common clinical symptom was biliary fistula observed in 78.3% of patients. In 28 patients, unsuccessful attempts to manage BDI were made prior to the admission to the Department in other centres. The repair procedure was mainly conducted by laparotomy (82.6%) and by the endoscopic approach (15.9%). Hepaticojejunostomy was the most common type of reconstruction following BDI (34.7%). CONCLUSIONS: The increase in the rate of iatrogenic bile duct injury remains a challenging surgical problem. The management of BDI should be multidisciplinary treatment. Referring patients with both suspected and confirmed iatrogenic BDI to tertiary centres allows more effective treatment to be implemented.


Assuntos
Ductos Biliares/lesões , Ductos Biliares/cirurgia , Colecistectomia Laparoscópica/efeitos adversos , Colecistolitíase/cirurgia , Doença Iatrogênica , Complicações Intraoperatórias/etiologia , Complicações Pós-Operatórias/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
13.
Ginekol Pol ; 85(8): 624-8, 2014 Aug.
Artigo em Polonês | MEDLINE | ID: mdl-25219145

RESUMO

Damage to the perineum, vulva, anal sphincters, rectal wall and the fascial structures of the pelvic floor may be caused by obstetric trauma. Emergency surgical treatment aims at control of the bleeding, anatomical reconstruction of the disrupted tissues and minimization of the risk of infection. Suturing of the rectal wall and mucosa of the anal canal is followed by reconstruction of the perineal body internal and external anal sphincters, vulva and the perineum. Delayed surgery is undertaken after the complete healing of the obstetric tear. All cicatricial fibers must be saved to reinforce sphincters and perineal body muscles suturing. Anal levators and perineal transvers muscles suturing is used for the rectovaginal septum and pelvic floor reconstruction. Anal sphincters are reconstructed by the 'overlapping' technique. X en Z suturing is used for a perineal skin plasty.


Assuntos
Canal Anal/lesões , Complicações do Trabalho de Parto/cirurgia , Diafragma da Pelve/lesões , Períneo/lesões , Canal Anal/cirurgia , Feminino , Humanos , Recém-Nascido , Complicações do Trabalho de Parto/etiologia , Diafragma da Pelve/cirurgia , Períneo/cirurgia , Complicações Pós-Operatórias/cirurgia , Gravidez , Ruptura , Técnicas de Sutura , Cicatrização/fisiologia
14.
Pol Przegl Chir ; 85(7): 377-80, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23945114

RESUMO

UNLABELLED: Mesh biomaterials have become the standard in the treatment of hernias, regardless the location. In addition to the obvious advantages of the methods based on implantable biomaterials, one should be aware of the possible complications, such as their migration to the abdominal organs. MATERIAL AND METHODS: The study group comprised patients operated at the Department of General, Gastroenterological Oncology, and Plastic Surgery during the period between 2008 and 2011, due to hernia surgery with mesh implantation. We also analysed the number of patients operated, due to complications of mesh migration during the same period. RESULTS: 368 patients were subject to mesh implantation, due to hernias during the period between 2008 and 2011. Three patients underwent surgery because of symptomatic migration of the mesh (ileus, fistula). CONCLUSIONS: The frequency of mesh migration is difficult to determine because of the different criteria of migration, observation period, and other factors. In patients after mesh implantation the potential migration of the biomaterial should be considered in case of unclear or acute abdominal symptoms.


Assuntos
Materiais Revestidos Biocompatíveis/efeitos adversos , Migração de Corpo Estranho/cirurgia , Hérnia Abdominal/cirurgia , Complicações Pós-Operatórias/cirurgia , Telas Cirúrgicas/efeitos adversos , Feminino , Migração de Corpo Estranho/diagnóstico , Herniorrafia/efeitos adversos , Humanos , Masculino , Complicações Pós-Operatórias/diagnóstico , Resultado do Tratamento
15.
Arch Med Sci ; 9(2): 283-7, 2013 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-23671439

RESUMO

INTRODUCTION: Proctocolectomy with ileal pouch-anal anastomosis (IPAA) was performed in ulcerative colitis (UC) for emergent or urgent indications in three stages. Since the three-step procedure imposes enormous demands on a patient, there was an attempt to introduce primary IPAA for urgent indications. The aim of this study was to compare early complications after Hartmann's colectomy (HC) and IPAA in a selected group of patients. MATERIAL AND METHODS: Medical records of 274 patients who underwent surgery for UC between 1996 and 2010 were retrospectively evaluated. Finally, a group of 77 patients with acute form of UC entered this study. RESULTS: All patients were divided into two groups. Group 1 consisted of 32 (42%) patients who underwent HC, whereas group 2 comprised 45 (58%) patients after IPAA. There was no postoperative mortality. Respiratory failure occurred in 8 (24%) patients after HC and in 6 (14%) patients who underwent IPAA. Intra-abdominal sepsis developed in 4 (12%) patients after HC and in 8 (17%) undergoing IPAA. Fascia dehiscence was present in 3 (8%) patients after HC and in 4 (9%) with IPAA. Bowel obstruction occurred in 1 (4%) patient after the former operation and in 3 (6%) patients after the latter one. Wound infection was diagnosed in 6 (20%) patients after HC and in 9 (20%) after IPAA. The differences between the investigated groups of patients were not statistically significant. CONCLUSIONS: The IPAA could be performed for urgent indications only in the patients with no critical dilatation of the colon or with active UC but without signs of severe malnutrition.

16.
Int J Oncol ; 42(1): 305-16, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23165777

RESUMO

The insulin-like growth factor (IGF)-1 gene consists of 6 exons resulting in the expression of 6 variant forms of mRNA (IA, IB, IC, IIA, IIB and IIC) due to an alternative splicing. The mechanisms of IGF-1 gene splicing and the role of local expression manifested by IGF-1 mRNA variants in colorectal carcinoma (CRC) have not been extensively investigated. Therefore, the aim of our study was to analyse the expression of IGF-1 mRNA isoforms [A, B, C, P1 (class I) and P2 (class II)], as well as the protein expression in CRC and control samples isolated from 28 patients. The expression of Ki-67 was also analysed and clinical data were obtained. For this purpose, we used quantitative real-time PCR (qPCR) and immunocytochemistry. The expression of mRNAs coding for all splicing isoforms of IGF-1 was observed in every tissue sample studied, with a significantly lower expression noted in the CRC as compared to the control samples. The cytoplasmic expression of IGF-1 protein was found in 50% of the CRC and in ~40% of the non-tumor tissues; however, no significant quantitative inter-group differences were observed. The expression of the IGF-1 gene in the 2 groups of tissues was controlled by the P1 and P2 promoters in a similar manner. No significant differences were detected in the expression of the IGF-1 A and B isoforms; however, their expression was significantly higher compared to that of isoform C. No significant differences were observed between the expression of Ki-67 mRNA in the CRC and control tissue even though the expression of the Ki-67 protein was higher in the CRC compared to the control samples. Ki-67 protein expression was associated with the macroscopic and microscopic aspects of CRC. A significant positive correlation was found between the local production of total mRNA and isoform A and the expression of Ki-67 mRNA, although only in the non-tumor tissues. In CRC samples, the local expression of the total IGF-1 mRNA and all splicing isoforms of IGF-1 mRNA decreased as compared to the normal colon tissues, although however, with conservation of both gene promoter activities and with the continued principal splicing IGF-1 mRNA isoforms.


Assuntos
Adenocarcinoma/genética , Processamento Alternativo , Colo/metabolismo , Neoplasias Colorretais/genética , Fator de Crescimento Insulin-Like I/genética , Isoformas de RNA/genética , RNA Mensageiro/genética , Adenocarcinoma/metabolismo , Adenocarcinoma/patologia , Adulto , Idoso , Biomarcadores Tumorais/genética , Estudos de Casos e Controles , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Feminino , Seguimentos , Humanos , Fator de Crescimento Insulin-Like I/metabolismo , Antígeno Ki-67 , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Estadiamento de Neoplasias , Prognóstico , Regiões Promotoras Genéticas/genética , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa
17.
Wiad Lek ; 66(3): 237-40, 2013.
Artigo em Polonês | MEDLINE | ID: mdl-24483029

RESUMO

The authors present a case of 58 years old woman suffering from complex pelvic floor pathology diagnosed with rectal prolapse, genitary organs prolapse, descending pelvic floor, rectocele and enterocele as well as advanced diverticular disease of the left colon. She suffered from chronic constipation. The surgery consisted of left hemicolectomy, hysterectomy, reconstruction of the pelvic floor and sacrocoloporectopexy using polypropylene mesh. The out-come complicated mesenteric vessels thrombosis, small bowel perforations and intraabdominal abscesses. Despite intensive care and subsequent ileal resections, debridement and drainage of the abscesses the patient died five months after beacause of multi organs insufficiency.


Assuntos
Abscesso Abdominal/etiologia , Perfuração Intestinal/etiologia , Oclusão Vascular Mesentérica/etiologia , Diafragma da Pelve/cirurgia , Prolapso de Órgão Pélvico/cirurgia , Telas Cirúrgicas/efeitos adversos , Abscesso Abdominal/cirurgia , Colectomia , Constipação Intestinal/complicações , Desbridamento , Diverticulite/complicações , Evolução Fatal , Feminino , Humanos , Histerectomia , Pessoa de Meia-Idade , Prolapso de Órgão Pélvico/complicações , Polipropilenos , Trombose/etiologia
18.
Acta Biochim Pol ; 59(4): 599-601, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23198279

RESUMO

The procedure of restorative proctocolectomy is associated with a complete removal of the colon and slight reduction of ileum length, which together can lead to systemic shortages of trace elements. Inflammatory changes in the pouch mucosa may also have some impact. However, there is no data on trace elements in pouchitis. Therefore, in the present study we aimed to assess the effect of acute pouchitis on the status of selected trace elements in rats. Restorative proctocolectomy with the construction of intestinal J-pouch was performed in twenty-four Wistar rats. Three weeks after the surgery, pouchitis was induced. Eight untreated rats created the control group. Liver concentrations of selected micronutrients (Zn, Cu, Co, Mn, Se) were measured in both groups six weeks later, using inductively coupled plasma mass spectrometry. Liver concentrations of trace elements did not differ between the study and the control groups. However, copper, cobalt and selenium concentrations [µg/g] were statistically lower (p<0.02, p<0.05 and p<0.04, respectively) in rats with severe pouchitis (n=9) as compared with rats with mild pouchitis (n=7) [median (range): Cu--7.05 (3.02-14.57) vs 10.47 (5.16-14.97); Co--0.55 (0.37-0.96) vs 0.61 (0.52-0.86); Se--1.17 (0.69-1.54) vs 1.18 (0.29-1.91)]. In conclusion, it seems that acute pouchitis can lead to a significant deficiency of trace elements.


Assuntos
Fígado , Pouchite/metabolismo , Oligoelementos , Animais , Colo/química , Colo/metabolismo , Colo/cirurgia , Humanos , Íleo/metabolismo , Íleo/cirurgia , Fígado/química , Fígado/metabolismo , Proctocolectomia Restauradora , Ratos , Ratos Wistar , Oligoelementos/isolamento & purificação , Oligoelementos/metabolismo
19.
Ginekol Pol ; 83(11): 849-53, 2012 Nov.
Artigo em Polonês | MEDLINE | ID: mdl-23379194

RESUMO

The authors present epidemiology etiology pathophysiology management, and treatment of constipation including proper qualification for surgery. Constipations can be divided into more common - primary and less frequent - secondary The latter may occur due to organic lesions of the large bowel, in the course of metabolic and endocrine disorders, or neurological and psychiatric diseases. Constipation may also be a side effect of multiple medications. In turn, primary constipation is either a slower movement of contents within the large bowel or twice as likely pelvic floor dysfunction with the inability to adequately evacuate the contents from the rectum. Symptoms such as infrequent defecation and decreased urge to defecate indicate rather colonic inertia whereas prolong straining even in case of loose stools, and feeling of incomplete evacuation are typical of obstructed defecation. Digital rectal examination reveals common anorectal defects presenting with constipation such as tumors, anal fissures and strictures, and rectocele, or less frequent changes such as rectal intussusception and enterocele. Proctologic examination should include the assessment of the anal sphincter tone and the pelvic floor movement. Barium enema or colonoscopy are necessary to confirm or exclude colorectal organic lesions, mostly in patients with alarm features. More accurate differentiation between slow transit constipation and obstructed defecation is possible with tests such as colonic transit time, defecography and anorectal manometry Treatment of constipation, irrespective of the cause, is initiated with lifestyle modification which includes exercise, increased water intake and a high-fiber diet. Pharmacologic treatment is started with osmotic agents followed by stimulant laxatives. In turn, biofeedback therapy is a method of choice for the treatment of defecation disorders. There is a small group of patients with intractable slow-transit constipation and descending perineum syndrome who require surgery Surgical treatment is also indicated in patients with symptomatic rectocele, and advanced rectal intussusception. Enterocele can be corrected during perineopexy performed for the descending perineum.


Assuntos
Constipação Intestinal/diagnóstico , Constipação Intestinal/terapia , Exame Retal Digital/métodos , Incontinência Fecal/diagnóstico , Incontinência Fecal/terapia , Adulto , Idoso , Canal Anal/fisiopatologia , Constipação Intestinal/etnologia , Incontinência Fecal/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Diafragma da Pelve/fisiopatologia , Doenças Retais/diagnóstico , Doenças Retais/terapia , Fatores de Risco , Índice de Gravidade de Doença
20.
Wideochir Inne Tech Maloinwazyjne ; 7(4): 311-4, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23362434

RESUMO

The authors present a 32-year-old male patient with incarceration of a recurrent esophageal hiatal hernia after laparoscopic repair. A life-threatening strangulation of the stomach and the transverse colon occurred within a few days after the operation. Relapse of hiatal hernias amounts to almost half of early complications characteristic for the laparoscopic approach. General recommendations regarding surgical technique as well as perioperative care have been proposed in order to decrease the risk of relapse. Also, routine contrast radiology on the first or second day following the laparoscopic operation facilitates early diagnosis of relapse of hiatal hernia with emergent reoperation. This may result in decreased morbidity and improved overall outcome of the treatment.

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