RESUMO
Clopidogrel is a thienopyridine derivative antiplatelet compound. The antiplatelet effects of clopidogrel originate through noncompetitive antagonism of the platelet ADP receptor, P2Y12, resulting in inhibition of platelet activation. Clopidogrel is now widely used in acute coronary syndromes and after percutaneous coronary interventions to reduce the risk of subsequent cardiovascular events. We report a case of acute migratory polyarthritis associated with the use of clopidogrel. This serves as only the second documented case of clopidogrel-associated arthritis in the United States, and the first to show that prasugrel may be considered as an alternative agent without short-term reoccurrence.
Assuntos
Artrite/induzido quimicamente , Piperazinas/uso terapêutico , Inibidores da Agregação Plaquetária/farmacologia , Inibidores da Agregação Plaquetária/uso terapêutico , Tiofenos/uso terapêutico , Ticlopidina/análogos & derivados , Clopidogrel , Humanos , Masculino , Pessoa de Meia-Idade , Piperazinas/farmacologia , Cloridrato de Prasugrel , Tiofenos/farmacologia , Ticlopidina/efeitos adversos , Ticlopidina/uso terapêuticoRESUMO
We report a case of a 26-year-old female, who presented at 34 weeks of an uncomplicated pregnancy with an acute ST elevation anterior wall myocardial infarction. Cardiac catheterization suggested a left main coronary artery dissection with pseudoaneurysm formation. The patient's course was complicated by congestive heart failure. She was initially managed conservatively by a multidisciplinary team including heart failure specialists, obstetricians, and cardiovascular surgeons. 4 days after admission, her LMC was imaged by dual-source 64 slice Cardiac computed tomography, coronary dissection was identified extending to the lumen, and the presence of pseudoaneurysm was confirmed. She underwent subsequently a staged procedure, which included placement of an intra-aortic balloon pump, cesarean section, and coronary artery bypass grafting. This case illustrates the utility of coronary artery CT imaging to assess the complexity and stability of coronary artery dissections, thereby helping to determine the need for, and timing of revascularization procedures.
Assuntos
Falso Aneurisma/diagnóstico por imagem , Dissecção Aórtica/diagnóstico por imagem , Aneurisma Coronário/diagnóstico por imagem , Complicações Cardiovasculares na Gravidez/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto , Dissecção Aórtica/complicações , Falso Aneurisma/etiologia , Aneurisma Coronário/cirurgia , Angiografia Coronária , Ponte de Artéria Coronária , Feminino , Insuficiência Cardíaca/etiologia , Humanos , Infarto do Miocárdio/complicações , Gravidez , Complicações Cardiovasculares na Gravidez/cirurgiaAssuntos
Ruptura Cardíaca/complicações , Ruptura Cardíaca/diagnóstico por imagem , Doenças Musculares/complicações , Infarto do Miocárdio/complicações , Músculos Papilares/diagnóstico por imagem , Ruptura do Septo Ventricular/complicações , Ruptura do Septo Ventricular/diagnóstico por imagem , Ruptura Cardíaca/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Musculares/diagnóstico por imagem , Doenças Musculares/cirurgia , Infarto do Miocárdio/diagnóstico por imagem , Infarto do Miocárdio/cirurgia , Músculos Papilares/cirurgia , Ruptura Espontânea/diagnóstico por imagem , Ruptura Espontânea/cirurgia , Resultado do Tratamento , Ultrassonografia , Ruptura do Septo Ventricular/cirurgiaRESUMO
BACKGROUND AND PURPOSE: Rapid eye movement (REM) sleep behavior disorder (RBD) has a known association with other medical conditions, including narcolepsy and neurodegenerative diseases such as synuclienopathies. RBD is currently treated with clonazepam as a first-line therapy. Recent research suggests that the pathophysiology underlying RBD may involve a dopaminergic deficiency, given its association with Parkinson syndromes and restless legs syndrome (RLS). We report on the efficacy of pramipexole, a dopaminergic D2-3 receptor agonist, in the treatment of RBD. PATIENTS AND METHODS: The first 10 consecutive patients presenting with a history and polysomnographically confirmed RBD were given pramipexole as either a single dose before bedtime or as a divided dose regimen with the first dose given in the early evening and the second dose at bedtime. Medication was titrated to control RBD symptoms and the clinical response was monitored through interviews with the patient, spouse, and close family members during the course of the study at regularly scheduled follow-up visits. RESULTS: The mean length of treatment was 13.1 months, and the average total evening dose of pramipexole at the end of the study was 0.89+/-0.31 mg. A divided dose regimen of pramipexole was used in 56% of patients remaining on pramipexole. We found that 89% of patients experienced either a moderate reduction or complete resolution in the frequency of RBD symptoms throughout the duration of the study. Moreover, 67% reported at least a moderate reduction in the severity of remaining symptoms. CONCLUSIONS: Pramipexole markedly reduced the frequency and severity of RBD symptoms and appeared to maintain efficacy for up to 25 months as assessed at follow-up visits. Clonazepam may have numerous unwanted side effects in the elderly or narcoleptics with RBD, such as prominent sedation and the potential exacerbation of underlying obstructive breathing in sleep. The potential role of pramipexole in improving RBD and its associated dopamine deficient syndromes warrants further research in the use of dopaminergic agonists as a potential first-line alternative therapy for RBD.