RESUMO
BACKGROUND: Earlier, we described morphological changes in rat ovaries in different terms after Biskind's operation elucidating the factors that affect the precancerous conditions and ovarian neoplasms appearance. The aim of the research was to identify tumor nature on the 120th day after modified Biskind's operation using immunohistochemical approach. RESULTS: We described morphological changes in rat ovaries on the 120th day after Biskind's operation, demonstrated development of theca-granulosa cell tumors, and differentiated between Sertoli-Leydig cell tumors and theca-granulosa cell tumors using monoclonal antibodies against Ingibin-alfa, Calretinin, Melan Ð. CONCLUSION: Modified Biskind's model could be used to study sex-cord tumors in rat ovaries.
Assuntos
Tumor de Células da Granulosa/etiologia , Tumor de Células da Granulosa/patologia , Ovário/patologia , Tumor da Célula Tecal/etiologia , Tumor da Célula Tecal/patologia , Animais , Biomarcadores Tumorais , Modelos Animais de Doenças , Suscetibilidade a Doenças , Feminino , Humanos , Imuno-Histoquímica , Ovariectomia/efeitos adversos , RatosRESUMO
Abdominoanal resection with descending of left colon on perineum, leaving additional part of a descended intestine, was performed. For the hemorrhage arrest the welding sutures were put on intestinal wall. According to morphological investigations data, a damage of intestinal wall in the zone of a welding suture application is a reversible one, it spreads from the electrode branch on 2-3 mm. The presence of undamaged structures witnesses the presence of an active regeneration process in tissues around the welding suture.
