RESUMO
A 64-year-old man underwent chemotherapy after radical cystectomy for bladder cancer (UC, G3, pT3aN1M0). Three years later, computed tomography showed a left adrenal mass, and we performed left adrenalectomy. Histological findings showed that the adrenal mass was a metastasis of the bladder cancer. Over 6 years after salvage chemotherapy, the patient had no evidence of metastasis to other parts of the body. In the case of a solitary metastasis of bladder cancer, surgical resection should be positively considered.
Assuntos
Neoplasias das Glândulas Suprarrenais/secundário , Neoplasias da Bexiga Urinária/patologia , Neoplasias das Glândulas Suprarrenais/terapia , Adrenalectomia , Idoso , Humanos , Masculino , Terapia de SalvaçãoRESUMO
We report a case of papillary adenocarcinoma inside a seminal vesicle cyst associated with contralateral renal agenesis in a 30-year-old man. Coexistence of a seminal vesicle cyst and tumors is rare. Surgical excision was performed but he died due to liver metastases one year later.
Assuntos
Adenocarcinoma Papilar/diagnóstico , Cistos/diagnóstico , Neoplasias dos Genitais Masculinos/diagnóstico , Rim/anormalidades , Glândulas Seminais , Adenocarcinoma Papilar/complicações , Adenocarcinoma Papilar/patologia , Adenocarcinoma Papilar/cirurgia , Adulto , Cistos/complicações , Cistos/cirurgia , Neoplasias dos Genitais Masculinos/complicações , Neoplasias dos Genitais Masculinos/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Glândulas Seminais/cirurgia , Tomografia Computadorizada por Raios XRESUMO
A cell line designated HTLS was established from the retroperitoneal liposarcoma. The HTLS line showed stable proliferation without interruption for 2 years and subcultivated over 35 times. The cells were elongated fibrous and spindle in shape, and neoplastic and pleomorphic features. The multinucleated giant cells with fine cytoplasm were seen. The cells proliferated slowly and the population doubling time was about 90 hours. The chromosome number showed a wide distribution of aneuploidy, the mode was hyperdiploid range (51-52), and many marker chromosomes were observed. The cells were transplantable into the submucosa of immunesuppressed hamster's cheek pouch and produced liposarcoma, while were not transplantable into subcutis of nude mice
Assuntos
Lipossarcoma/patologia , Adulto , Aneuploidia , Animais , Linhagem Celular Tumoral , Proliferação de Células , Cromossomos Humanos/genética , Cricetinae , Feminino , Humanos , Cariotipagem , Lipossarcoma/genética , Mesocricetus , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Transplante de Neoplasias , Neoplasias Retroperitoneais/genética , Neoplasias Retroperitoneais/patologia , Fatores de TempoRESUMO
Human uterine cervical malignant lymphoma (B-cell type) was cultured and the cell line (HIUML) was newly established. The HIUML cells were round in shape and had a tendency to make floating clusters. The cells had a smooth surface or protrusion on the margin of the cytoplasm, and proliferate in floatation. The population doubling time was about 32 hours and 42 or more passages were successfully observed in two years. The HIUML cells were not transplantable into nude mice but were successfully done in the cheek pouch of hamster with formation of malignant lymphoma. Epstein-Barr virus was detected in the HIUML cells.
Assuntos
Linfoma de Células B/patologia , Neoplasias do Colo do Útero/patologia , Animais , Antígenos CD/análise , Linhagem Celular Tumoral , Proliferação de Células , Cricetinae , Feminino , Herpesvirus Humano 4/isolamento & purificação , Humanos , Cariotipagem , Linfoma de Células B/genética , Linfoma de Células B/virologia , Mesocricetus , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Pessoa de Meia-Idade , Fatores de Tempo , Neoplasias do Colo do Útero/genética , Neoplasias do Colo do Útero/virologiaRESUMO
Despite recent advances in the application of chemotherapy to ovarian cancer, the development of alternative therapies that retain activity against drug-resistant-tumors remains a high priority. We analyzed a number of cultured ovarian cancer cell lines of different tissue types for the presence or absence of sensitivity to various anticancer drugs as well as expression patterns of oncogene products (erbB-2, EGFR, bcl-2). As a result, we identified oncogene products that were related to resistance. Using 9 cultured cell lines of ovarian cancers (serous, mucinous, endometrioid, clear, undifferentiated), sensitivities to anticancer drugs were investigated using the MTT assay. The phenotypes of oncogene products expressed by the above cultured cell lines were analyzed by Western blotting. The oncogene products involved in resistance to anticancer drugs were identified by multivariate analysis. Positive correlation between the resistance to anticancer drugs and the oncogene products was obtained by multivariate analysis for (a) CDDP and erbB-2 (b) x p-16 and erbB-2, and (c) MMC and EGFR. Correlation between resistance to anticancer drugs and expression of certain oncogene products was obtained in ovarian cancers, suggesting that sensitivity to anticancer drugs could be predicated prior to chemotherapy.
