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1.
J Surg Oncol ; 7(4): 323-7, 1975.
Artigo em Inglês | MEDLINE | ID: mdl-1177466

RESUMO

Somatic cell hybridization (fusion) was carried out between cells of the murine lymphoma L-5178Y(r) and peripheral human lymphocytes. The L-5178Y(r) line is deficient in hypoxanthine-guanine phosphorybosyl transferase (HGPRT). Using a selective medium system, it was possible to isolate hybrid cell clones having the complete complement of murine chromosomes as well as the human X chromosome on which the gene for HGPRT is located. This model system may be used to study the effect of the human X chromosome on the phenotype of the murine lymphoma.


Assuntos
Células Híbridas , Modelos Biológicos , Neoplasias/genética , Animais , Fusão Celular , Humanos , Cariotipagem , Linfócitos , Linfoma , Camundongos , Cromossomos Sexuais
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