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1.
Open Med (Wars) ; 18(1): 20230843, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38025545

RESUMO

A prospective observational study (ClinicalTrial ID: NCT05771415) was conducted to compare placental oxygenation in low-risk, uncomplicated term pregnancies measured by near-infrared spectroscopy (NIRS) in relation to the placental maturity grade determined by ultrasound assessment according to the Grannum scale. We included 34 pregnancies divided into two groups according to placental maturation. For each pregnancy, measurements were taken at the site above the central part of the placenta (test) and at the site outside of the placenta on the lower abdomen (control). Student's t-test was used to compare tissue oxygenation index (TOI) values among the study groups. The normality of distribution was proven by the Kolmogorov‒Smirnov test. In women with low placental maturity grade, the mean TOI value above the placenta was 70.38 ± 3.72, which was lower than the respective value in women with high placental maturity grade (77.99 ± 3.71; p < 0.001). The TOI values above the placenta and the control site were significantly different in both groups (70.38 ± 3.72 vs 67.83 ± 3.21 and 77.99 ± 3.71 vs 69.41 ± 3.93; p < 0.001). The results offer a new perspective on placental function based on specific non-invasive real-time oxygenation measurements. Unfortunately, and because of technical limitations, NIRS cannot yet be implemented as a routine clinical tool.

2.
J Perinat Med ; 51(5): 607-613, 2023 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-36423330

RESUMO

OBJECTIVES: To determine the morphological characteristics of the placentas from COVID-19 positive mothers in regard to the trimester of COVID-19 infection onset and low weight molecular heparin (LMWH) treatment. METHODS: Placentas were collected in the period April 1st till September 1st 2021 after delivery at Department of Obstetrics and Gynecology University Hospital Split, Croatia, and sent for pathological examination. Medical history and pathology reports were used to collect the data. Pregnant women were divided based on the onset of COVID-19 infection and stratified into low molecular weight heparin (LMWH)+ or LMWH-. Depending on the data distribution, the following test were used: chi-squared test. Student's t-test, Mann-Whitney U test, ANOVA and Kruskal-Wallis test. RESULTS: In 38% of patients the onset of COVID-19 infection was the 1st trimester of pregnancy, in 27% in the 2nd and 35% of women were infected in the 3rd trimester The fetal vascular malperfusion (FVM) occurrence was statistically significantly higher in the LMWH- group and if the onset of infection was in the 2nd trimester, while the perivillous fibrin deposition was most likely to happen if the COVID-19 infection that occured in the 1st trimester of pregnancy. CONCLUSIONS: The onset of COVID-19 infection has the influence on trophoblast damage and subsequent morphological appearance of the placenta. LMWH use in COVID positive pregnant women decreases the rate of the FVM in examined placentas.


Assuntos
COVID-19 , Placenta , Feminino , Gravidez , Humanos , Placenta/patologia , COVID-19/complicações , COVID-19/patologia , Heparina de Baixo Peso Molecular/uso terapêutico , Primeiro Trimestre da Gravidez , Trofoblastos , Fibrinolíticos
3.
Croat Med J ; 60(6): 508-514, 2019 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-31894916

RESUMO

AIM: To investigate the relationship between maternal pre-pregnancy body-mass index (BMI) and neonatal birth weight. METHODS: The observational study included 2906 mothers and their neonates born from 2005 to 2011 at the Department of Gynecology and Obstetrics, Split University Hospital Center. Mothers with singleton term pregnancies who were overweight before pregnancy (BMI 25-29.9 kg/m2) were compared with those with normal pre-pregnancy weight (BMI 18.5-24.9 kg/m2). BMI change was assessed as a predictor of birth weight, categorized as small (SGA), appropriate (AGA), or large for gestational age (LGA). RESULTS: The rate of SGA infants was significantly lower (n=199; 6.8% vs n=1548; 9.2%) and the rate of LGA infants significantly greater among pre-pregnancy overweight mothers compared with normal-weight mothers (n=371; 12.8% vs n=1302; 7.8%; P<0.001 both). Overweight mothers had a significant probability of delivering an SGA neonate when they gained less than 6 kg, as compared with 8 kg among normal-weight mothers. They had a significant probability of delivering an LGA neonate when they gained more than 14 kg, compared with more than 20 kg among normal-weight mothers. BMI change was a more consistent indicator, suggesting that the ranges of 3.0-7.9 kg/m2 in overweight and 2-5.9 kg/m2 in normal-weight women were not associated with a significant increase in the rate of SGA or LGA. CONCLUSION: Maternal height seems to be an important factor in optimal weight gain definition, suggesting that BMI change should be a preferred measure of pregnancy-related weight.


Assuntos
Peso ao Nascer , Índice de Massa Corporal , Macrossomia Fetal/etiologia , Ganho de Peso na Gestação , Recém-Nascido Pequeno para a Idade Gestacional , Sobrepeso/complicações , Adulto , Estatura , Estudos de Casos e Controles , Feminino , Humanos , Peso Corporal Ideal , Recém-Nascido , Sobrepeso/fisiopatologia , Gravidez , Adulto Jovem
4.
Hypertens Pregnancy ; 36(1): 16-20, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27657362

RESUMO

OBJECTIVE: To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies. METHODS: Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index. The CK7 antibody was used to distinguish DC from EVTB. RESULTS: DC and EVTB proliferation was significantly higher in PE placentas. EGFR and EGF expression showed no significant difference. CONCLUSION: Higher DC and EVTB proliferation in PE could contribute to PE development.


Assuntos
Proliferação de Células , Fator de Crescimento Epidérmico/metabolismo , Receptores ErbB/metabolismo , Placenta/metabolismo , Pré-Eclâmpsia/metabolismo , Adulto , Feminino , Humanos , Placenta/patologia , Pré-Eclâmpsia/patologia , Gravidez , Trofoblastos/metabolismo , Trofoblastos/patologia
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