The proinflammatory mediator's production from ischemic brain during carotid endarterectomy.

AIM: The aim of the study was to determine the quantity of produced mediators of inflammation (cytokines and eicosanoids), during carotid endarterectomy (CEA), which are factors of ischemic damage of the brain. METHODS: Two groups (A and B) of 15 patients each, with internal carotid backpressure >30 mmHg were operated in our institution. We did not use a shunt in Group A during CEA and group B was operated upon with a shunt. Plasma concentrations of Interleukin-1b (IL-1b), Thromboxane B2 (TXB2), Prostaglandin E2 (PGE2) and tumor necrosis factor-a (TNFa) were measured by enzyme-linked immunosorbent assay (ELISA) technique. RESULTS: We measured gradual increase of levels of IL-1b and TXB2 during cross-clamping and during reperfusion in group A (P<0.05). The levels of TNFa increased only during reperfusion (P<0.05). The concentration of IL-1b and TNFa remained almost stable in group B, whereas the concentration of TXB2 reduced but not significantly (P>0.05). The levels of PGE2 remained stable in both groups. CONCLUSION: We should consider the increase of proinflammatory mediators during carotid cross-clamping when no shunt is used. The critical concentration of these mediators that threaten the brain's vitality is not yet detected. However, the clinical significance of this is unclear, since there were no perioperative strokes.

[Research in the dental laboratories in Thessaloniki relatively to the planning and the kind of the fixed prosthetic constructions]. / Hereuna sta odontotechnika ergasteria Thessalonikes schetika me te schediase kai to eidos ton akineton prosthetikon ergasion.

It is well known that Prosthetics is the part of Dentistry that needs the dentist's and D. technician's cooperation in order to be completed. For this reason the aim of our research was on one hand to record the planning and the kinds for the fixed bridge work that proceed from the cooperation of the two sides and on the other hand to evaluate the results, to locate the weak points and to give the possibility to our department to obtain clearer and more entire of the Prosthetic treatment given by the dentists and D. technicians. So from this research and the answers to the four sections which refer to the above mentioned subject, we had some information about the plannings and the kinds of the crowns, the way of their forwarding the importance of the aesthetic part of the constructions and at last the problems which are created on the dental laboratories by the way which the teeth are prepared.