[Comparative study of age-related effectiveness of tri- and tetracyclic antidepressants]. / Sravnitel'no-vozrastnoe izuchenie éffektivnosti trekh- i chetyrekhtsiklicheskikh antidepressantov.

A comparative age-associated study of the efficacy and side effects of amitriptyline and maprotyline was carried out in a group of 93 patients over 50. The health status of the patients was assessed with the aid of Hamilton's depression scale and the scale of side effects on days 0, 7 and 28 of the therapy. It has been discovered that on day 28 maprotyline caused a more complete reduction of depressive disorders as compared to amitriptyline. Maprotyline produced a more intensive action on the anxious component of depression. There were differences in the intensity and range of side effects evoked by amitriptyline and maprotyline. Unlike maprotyline, the antidepressive effect of amitriptyline developed in a group of patients over 70, at later stages of the therapy. Therefore, it is more advisable that tetracyclic antidepressants be used for the treatment of senile patients.

[Acoasmatic hallucinosis in tardive schizophrenia]. / Ob akoazmaticheskom galliutsinoze pri pozdnei shizofrenii.

A study of late schizophrenia manifested in the syndrome of involutional paranoid has allowed the identification of the clinical variant of such psychoses (44 observations) differing from the classical forms in that the clinical picture was predominated by elementary acoustic hallucinations (acoasms). The phenomenological analysis has established that the formation of the clinical picture is determined by acoasms and also the resulting delirium of imagination and delirious interpretations. Two major variants of such psychoses have been specified and described ("the syndrome of acoasmatic hallucinosis" and "the hallucinational-delirious syndrome with the predominance of acoasms"). It has been established that each of these syndromal variants may determine the picture of the disease throughout its course or be one of the sequential stages of its development.