[The evaluation of oxidative modification of proteins in patients with chronic disseminated dermatosis].

The analysis was made concerning oxidative modification of proteins of blood serum and erythrocytes in patients with chronic disseminated dermatosis. The high degree of total oxidative modification of proteins was established in patients with psoriasis and atopic dermatitis. The increase of level of oxidized derivatives of apoproteins in compound of lipoproteins of low density under psoriasis, atopic dermatitis and pemphigus was detected The increase of amount of carbonyl derivative of oligopeptids under psoriasis was revealed. In patients with resistance to applied therapy the statistically significant decrease of total oxidative modification of proteins of blood serum and erythrocytes was detected. This occurrence is possibly related to derangement of process of proteolytic destruction of proteins.

[Are we controlling the sedation in ICU? A multicenter study results].

The aim of this study is to evaluate the issues of sedation and analgesia in all-purpose ICUs in Russia. To obtain that, a single-day observational survey was performed in 55 ICUs of Ural and Siberia regions. This work enabled to describe the targets, instruments of control and patterns of sedative and analgetics and sedatives prescription, as well as to make conclusions about issues in this area and possibilities of creation and necessity of analgesia and sedation standards. The study has shown a decent percentage of use of standardized scales evaluating pain in ICU and predominance of effectivae drugs and analgesia patterns, which leads to "formalization" of analgesia and decrease of it's effectiveness. Sedation indications do not satisfy the modern concept, sedation level evaluation scores are used only in 13%, schemes and drugs are traditional. The results of this study may serve as a reason for discussion of necessity of introducing of sedative and analgetic therapy in ICU standarts.