1.
Tissue Antigens
; 70(2): 144-50, 2007 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17610419
RESUMO
Unusual HLA-A'null' alleles because of an entire gene deletion were found in three apparently unrelated Japanese families with leukemia patients. Inclusion of the entire HLA-A gene in the deletion was confirmed by polymerase chain reaction direct sequencing of the surrounding regions of HLA-A. Further localization of the breakpoints of the HLA-A deletion at the centromeric and telomeric sides was performed, and these families were shown to possess the identical deletion. We then determined the genomic sequence of the HLA-A-deleted haplotype. Surprisingly, the haplotype turned out to carry an insertion of an SVA (SINE-VNTR-Alu) retrotransposon of 2 kb as well as the 14 kb deletion that included the entire HLA-A gene.
Assuntos
Deleção de Genes , Antígenos HLA-A/genética , Retroelementos/genética , Feminino , Haplótipos/genética , Humanos , Masculino , Linhagem
2.
Chem Pharm Bull (Tokyo)
; 21(2): 404-14, 1973 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4753311