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1.
Clin. transl. oncol. (Print) ; 25(8): 2350-2364, aug. 2023. ilus
Artigo em Inglês | IBECS | ID: ibc-222413

RESUMO

Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through “microRNA sponges”. The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach (AU)


Assuntos
Humanos , Lactente , Criança , MicroRNAs/genética , MicroRNAs/metabolismo , Neoplasias da Retina/genética , Neoplasias da Retina/terapia , Retinoblastoma/genética , Retinoblastoma/terapia , Ácidos Nucleicos Livres/genética , Biomarcadores Tumorais
2.
Clin Transl Oncol ; 25(8): 2350-2364, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37000290

RESUMO

Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through "microRNA sponges". The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach.


Assuntos
MicroRNAs , Neoplasias da Retina , Retinoblastoma , Criança , Lactente , Humanos , RNA Circular/genética , Retinoblastoma/genética , Retinoblastoma/terapia , MicroRNAs/genética , MicroRNAs/metabolismo , Biomarcadores , Neoplasias da Retina/genética , Neoplasias da Retina/terapia
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