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2.
Pediatr Hematol Oncol ; 18(7): 459-63, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11594709

RESUMO

Various kinds of second malignant neoplasms after sucessful treatment for childhood acute leukemia have been reported. The authors describe an unusual case of an olfactory neuroblastoma in a patient previously treated for childhood acute leukemia including autologous bone marrow transplantation. The prophylactic cranial irradiation and the total body irradiation during autologous bone marrow transplantation may have induced the development of their patient's olfactory neuroblastoma. Although a second primary olfactory olfactory neuroblastoma is rare is rare, it should be added to the list of second malignant neoplasms in the sinonasal region.


Assuntos
Estesioneuroblastoma Olfatório/etiologia , Segunda Neoplasia Primária/etiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Transplante de Medula Óssea , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/secundário , Criança , Estesioneuroblastoma Olfatório/patologia , Evolução Fatal , Feminino , Humanos , Segunda Neoplasia Primária/patologia , Transplante Autólogo , Irradiação Corporal Total/efeitos adversos
4.
Cancer Genet Cytogenet ; 104(2): 115-8, 1998 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-9666804

RESUMO

A boy with Down syndrome who developed myelodysplastic syndrome after regression of transient abnormal myelopoiesis (TAM) is described. His blast cells in TAM had other chromosome abnormalities in addition to trisomy 21;50,XY,+21c,+12,+14,+21. Serial chromosome analysis in follow-up showed abnormal clones involving monosomy 7. Myelodysplastic syndrome was diagnosed. Because two clones had different karyotypes, they might have derived from different clones.


Assuntos
Aberrações Cromossômicas , Síndrome de Down/complicações , Leucopoese , Síndromes Mielodisplásicas/genética , Células Clonais , Síndrome de Down/genética , Humanos , Hibridização in Situ Fluorescente , Recém-Nascido , Cariotipagem , Masculino , Síndromes Mielodisplásicas/complicações
5.
Acta Haematol ; 98(2): 109-12, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9286308

RESUMO

We report a case of transient abnormal myelopoiesis (TAM) with Down's syndrome. As the blast cells had additional chromosome abnormalities (50,XY,+12,+14,+21 x 2), a possibility of acute leukemia was considered from a cytogenetic point of view. But the abnormal clone gradually disappeared without antileukemic therapies. Viewing it together with previous reports of TAM with additional chromosome abnormalities in Down's syndrome babies, its presence does not immediately indicate an aggressive clinical course as in acute leukemia and spontaneous complete hematological remission may be achieved. Thus, a careful follow-up should precede cytogenetic findings helping to determine the therapeutic intervention.


Assuntos
Aberrações Cromossômicas/genética , Síndrome de Down/genética , Transtornos Mieloproliferativos/genética , Adulto , Medula Óssea/patologia , Transtornos Cromossômicos , Síndrome de Down/complicações , Feminino , Humanos , Recém-Nascido , Masculino
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