Bergenia stracheyi extract-based hybrid hydrogels of biocompatible polymers with good adhesive, stretching, swelling, self-healing, antibacterial, and antioxidant properties.

An ultra-stretchable, quickly self-healable, adhesive hydrogel with efficient anti-oxidant and anti-bacterial activities makes it potential wound dressing material, particularly in healing skin wounds. However, it is highly challenging to prepare such hydrogels with a facile and efficient material design. Given this, we opine the synthesis of medicinal plant Bergenia stracheyi extract-loaded hybrid hydrogels of biocompatible and biodegradable polymers like Gelatin, Hydroxypropyl cellulose, and Polyethylene glycol with acrylic acid via in situ free radical polymerization reaction. The selected plant extract is rich in phenols, flavonoids, and tannins and found to have important therapeutic benefits such as anti-ulcer, anti-Human Immunodeficiency Virus, anti-inflammatory, and burn wound healing effects. The polyphenolic compounds in the plant extract interacted strongly via hydrogen bonding with -OH, -NH2, -COOH, and C-O-C groups of the macromolecules. The synthesized hydrogels were characterized by fourier transform infrared spectroscopy and rheology. The as-prepared hydrogels demonstrate ideal tissue adhesion, excellent stretchability, good mechanical strength, broad-band anti-bacterial capability, and efficient anti-oxidant properties, in addition to quick self-healing and moderate swelling properties. Thus, the aforementioned properties attract the potential use of these materials in the biomedical field.

Effect of nanoemulsion-loaded hybrid biopolymeric hydrogel beads on the release kinetics, antioxidant potential and antibacterial activity of encapsulated curcumin.

Nanoemulsion encapsulated in the hydrogel beads are important entrants for loading hydrophobic active ingredients for enhancing their bioavailability and biological activities relevant in the pharmaceutical, food and cosmetic industries. Herein, we report the formulation of curcumin-loaded nanoemulsion encapsulated in ionotropic hybrid hydrogel beads of alginate, chitosan, gelatin and polyethylene oxide for effective delivery of curcumin. The release behaviour in simulated gastric and intestinal fluids (SGF and SIF) at 37 °C showed faster release in SGF which could be explained on the basis of mesh size, the extent of hydration and the complexation of the curcumin with the Ca2+ ions present within the hydrogel network. The free radical scavenging and antibacterial activities of the released curcumin in SGF were significantly greater than in SIF. This study shows promises of such hybrid systems, ignored so far, for proper encapsulation, protection and delivery of curcumin for the development of functional foods and pharmaceutics. The high structural stability of these nanoemulsion carriers and their effective delivery of curcumin provide a novel and tailored formulation out of existing polymers with plethora of advantages for oral drug delivery. Moreover, this study opens new door for different possibilities to improve the physicochemical characteristics and delivery of bioactive molecules like curcumin.