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Exp Clin Endocrinol Diabetes ; 122(3): 149-53, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24643691

RESUMO

CONTEXT: The supervised 72-h fast remains the gold standard test for the diagnosis of endogenous hyperinsulinism and has recently been suggested to be shortened or even avoided. OBJECTIVE: This study aimed to evaluate whether measurement of blood glucose, insulin and C-peptide levels after a 12 h overnight fast (mini-fasting test), in at least 3 consecutive days, could allow making or ruling out diagnosis of endogenous hyperinsulinism, according to the Endocrine Society's recent guidelines. PATIENTS AND METHODS: We performed 12 h mini-fasting test in at least 3 consecutive days, dosing blood glucose, insulin and C-peptide levels in 26 inpatient patients with pathologically proven endogenous hyperinsulinism. RESULTS: In our series, 100% of patients showed insulin levels of at least 3 µU/ml and C-peptide levels of at least 0.6 ng/ml concomitant with symptomatic hypoglycemia (≤ 55 mg/dl). CONCLUSION: It leads to the conclusion that mini-fasting test might avoid, in most cases, prolonged fasting test for the diagnosis of hypoglycemia due to endogenous hyperinsulinism.


Assuntos
Glicemia/metabolismo , Peptídeo C/sangue , Jejum , Hiperinsulinismo/diagnóstico , Insulina/sangue , Adolescente , Adulto , Biomarcadores/sangue , Pré-Escolar , Jejum/sangue , Feminino , Seguimentos , Humanos , Hiperinsulinismo/sangue , Lactente , Insulinoma/sangue , Insulinoma/metabolismo , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Resultado do Tratamento , Adulto Jovem
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