[Genetic monitoring of the population of the Carpathian region under anthropogenic pollution of the environment]. / Henetychnyi monitorynh naselennia Prykarpattia v umovakh antropohennoho zabrudnennia navkolyshn'oho seredovyshcha.

A genetic monitoring was conducted in a number of ecological regions of Precarpathia on the basis of clinical and epidemiological indices for the frequency of spontaneous abortions, specific weight of multiple birth, dynamics of number born living over the twelve-year period of 1985-1996, with the incidence and nosological spectrum of congenital malformations and hereditary diseases having been characterized. Negative genetic changes were disclosed in those communities under health-hazard conditions. Predominance of spontaneous abortions early in gestation was established together with decline in birth rate, increase in perinatal mortality, congenital malformations, and hereditary diseases in neonates and in children having died in the perinatal period.

[The complex assessment of the consequences of anthropogenic environmental pollution and the principles for their prevention]. / Kompleksna ostinka mutahennykh naslidkiv antropohennoho zabrudnennia dovkillia i pryntsypy ïkh profilaktyki.

Genetic monitoring on the basis of clinical-epidemiologic indices of congenital and hereditary pathology among newborns and spontaneous abortions as well as morphogenetic finding analysis in different age group representatives have been carried out. Mutation process dynamics in various ecological zone populations has been established. Dermatoglyphics and karyograme changes have been revealed their expressiveness depended on the general state of the organism, age and hereditary predisposition to polygenic diseases.

[The results of cytogenetic studies of workers in industrial enterprises]. / Rezul'taty tsytohenetychnykh doslidzhen' u robitnykiv promyslovykh vyrobnitstv.

Cytogenetic monitoring of workers of large industrial enterprizes showed the presence of chromatide aberrations in the peripheral blood lymphocytes, which were more manifest in workers of chemical and byproduct cokeplants, and somewhat less apparent in metallurgists. The frequency of metaphases involving chromosomal aberrations is dependent upon the duration of occupational exposure to chemical mutagens. However, the number of chromosomal abberrations does not appear to be influenced by chemical factors remaining essantially the same. The human embrion genome sensitivity to the chemical mutagen action was found to be much higher than that of somatic cells of the adults occupationally exposed to alterating factors. Use of complexes of antioxidants (tocopheroli acetas, quercetin, splenin) makes for reduction in the number of chromosomal aberrations in workers engaged in chemical industry.

[An evaluation of the genetic effect of the action of chemical industry factors]. / Otsinka henetychnoho efektu diï faktoriv khimichnoho vyrobnytstva.

The complex cytologic and morphometric investigation of buccal epitheliocytes of 393 children from various ecologic zones has been carried out. Changes in indices of genome functional status due to the combined effect of chemical factors have been determined. The degree of manifestation of these characters depends on environmental conditions and the age of children.