[Oxygen-dependent processes in the blood cells from children with arterial hypertension concomitant with biliary dyskinesia].

Age individuality is characterized by an imbalance of the molecular mechanisms of antioxidant defense in adolescents with arterial hypertension and biliary dyskinesia, as documented by an enzyme imbalance of the first line of antioxidant defense and H2O, accumulation, by a substantial increase in glutathione peroxidase activity, and by inhibition of the activity of glutathione-dependent enzymes. The considerable rise of 2,3-diphosphoglycerate suggests tissue hypoxia. With this, enhanced neutrophil elastase activity causes damage to the structural components of vascular wall connective tissue, resulting in the development of endothelial dysfunction.

[Comparative characteristics of antioxidant status in women with diabetes type 2 of different age groups].

The purpose of this study was to evaluate the metabolic processes in women with diabetes mellitus type 2 of different age groups. It is established that hyperglycemia in aged women is characterized by the development of pronounced oxidative stress, which is the result of changes in the primary structure of protein molecules due to non enzymatic glycosylation of amino acid residues in the active sites. It is known that observed depletion of reduced glutathione pool is associated with high risk of genotoxicity, because it correlates with activation of mitochondrial, chromatin dysfunction and fragmentation of the DNA. In addition, hydroperoxides of polyunsaturated fatty acids formation leads to necrosis and apoptosis. It can be assumed that the diabetes mellitus type 2 triggers processes of apoptosis, which leads to the activation of aging programs and increase the mortality of patients. Obviously, the change in the concentration of thiol antioxidants, as well as the change in concentration of LPO molecular products may be one of the criteria for evaluation of aging and the efficiency of the treatment of patients.

[Peculiarities of metabolic rearrangement of gas-transporting function of the blood in the pregnant women under the influence of medical ozone applied in obstetrical practice].

This clinical and laboratory study was designed to evaluate the influence of an ozone-oxygen mixture on the characteristics of blood oxygen supply in pregnant women presenting with chronic placental insufficiency. The study has demonstrate that dosed ozone application modulates the oxygen-transporting function of the blood and promotes adaptive capacities of the organism by activation of aerobic metabolism and stabilization of cellular membranes. It is concluded that the proposed method can be recommended for the treatment of women with the complicated course of pregnancy in order to improve their endurance of and resistibility to the action of hypoxemia.

[The activities of red blood cell superoxide dismutase and catalase and serum alkaline phosphatase in onychodystrophy in women in the stage of nail rejection].

The resistance to a dystrophic process and lysis and the degree of clinical signs in nail lesions in different stages of onychodystrophy were found to be associated with the activity of alkaline phosphatase. A relationship was established between the magnitude of the blood activity of the enzymes superoxide dismutase and catalase with a drop in the serum activity of alkaline phosphatase. At the same time, there was a correlation between the rate of development of onychodystrophy and the magnitude of a change in the activity of antioxidant defense enzymes.

[Peptide-bound oxyproline and the activity of alkaline phosphatase in the serum of women with onychodystrophy].

A clinicobiochemical analysis has revealed a relationship between the elevated peptide-bound oxyproline levels and the lower activity of alkaline phosphatase in women and the presence of the early symptom stratified nails. The degree of the elevated peptide-bound oxyproline levels is informative of the early manifestations of the damage, which is of diagnostic value and enables treatment to be used in proper time. In a group of young subjects with onychodystrophy, the significant increase of peptide-bound oxyproline with the decreased activity of alkaline phosphatase in the serum may reflect the activation of adaptive reactions. The older the organism is, the less intensity of an adaptive reaction to hypoxia that is a principal of onychodystrophy.