RESUMO
The data on cytogenetic examination concerning the offspring of the Chernobyl accident liquidators (cleanup personnel) have been obtained. It has been established that spontaneous chromosomal aberrations level before folic acid administration was 1,8 times higher than that value after its employment (4,45 to 2,42 %, p < 0,01). In lymphocyte cultures treated with mitomycin C accompanied by folic acid it was 4,5 times higher before their administration (23,95 to 5,36 %, p < 0,001). The data obtained confirm a possibility of stabilization of genetic apparatus in offspring of the Chernobyl disaster liquidators after folic acid administration.
Assuntos
Acidente Nuclear de Chernobyl , Aberrações Cromossômicas , Ácido Fólico/farmacologia , Leucócitos Mononucleares/patologia , Militares , Exposição Ocupacional , Adolescente , Células Cultivadas , Criança , Aberrações Cromossômicas/efeitos dos fármacos , Doença Crônica , Análise Citogenética , Feminino , Ácido Fólico/uso terapêutico , Gastroenteropatias/genética , Gastroenteropatias/prevenção & controle , Humanos , Masculino , Mitomicina/farmacologia , Neurastenia/genética , Neurastenia/prevenção & controle , Exposição PaternaAssuntos
Infecções por HIV/prevenção & controle , Hospitais Comunitários , Doenças Profissionais/prevenção & controle , Adulto , Educação , Serviço Hospitalar de Emergência , Feminino , Humanos , Masculino , Corpo Clínico Hospitalar , Pessoa de Meia-Idade , Enfermeiras e Enfermeiros , Fatores de Risco , Federação RussaRESUMO
Frequency distribution of HLA antigens of A and B loci was examined in 138 adolescent boys aged 14-18 with delayed sexual development (DSD) of stages I-III, residing in the north-eastern region of Ukraine. Increase of A28- and B40-antigens and haplotypes A1-B40, A28-B40, A10-B40 determination frequencies was established. There were revealed positive and negative correlation between some of HLA antigens and DSD. Relative and attributive risks of DSD formation were calculated.
Assuntos
Antígenos HLA/genética , Puberdade Tardia/genética , Adolescente , Alelos , Distribuição de Qui-Quadrado , Frequência do Gene , Haplótipos , Humanos , Masculino , Fenótipo , Puberdade Tardia/imunologia , Fatores de Risco , UcrâniaRESUMO
Examinations of 98 healthy children and prepubertal and pubertal adolescents have revealed sex-related differences in blood plasma levels of beta-endorphin and methionine-enkephalin: the content of these peptides was higher in pubertal boys. Blood plasma leucin enkephalin content of boys and girls was virtually unchanged over the entire period of sexual maturation. Analysis of correlations helped detect the relationship between the examined peptides and the end product of catecholamine metabolism, vanilmandelic acid, and a negatively significant relationship between beta-endorphin and serotonin levels.
