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Heredity (Edinb) ; 94(1): 101-7, 2005 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-15536487

RESUMO

A new approach to multivariate genetic analysis of complex organismal traits is developed. It is based on examination of the distribution of parental strains and the F1 and F2 hybrids in a multidimensional space, and the determination of the directions corresponding to heterozygosity, epistatic and additive gene effects. The effect of heterozygosity includes variability produced by interaction between and within heterozygous loci. The additive gene effects and the remaining epistatic interactions between the homozygous loci can be visualized separately from the effects of heterozygosity by an appropriate projection of the points in multidimensional space. In all, 20 morphological, physiological and behavioural characters and 21 craniometric measures were studied in crosses between two laboratory rat strains. Linear combinations of craniometric and of morphophysiological characters with a high narrow-sense heritability could be identified. These combinations characterized the organismal stress response, which had been selected for in one of the strains. The prospects for the practical application of the new approach and also for the evaluation of the contribution of the genetic diversity to phenotypic variability in animals in natural populations are discussed.


Assuntos
Epistasia Genética , Variação Genética/genética , Animais , Comportamento Animal , Pressão Sanguínea , Corticosterona/metabolismo , Feminino , Genótipo , Heterozigoto , Homozigoto , Masculino , Modelos Genéticos , Fenótipo , Ratos , Ratos Endogâmicos , Seleção Genética , Estresse Psicológico/genética , Estresse Psicológico/fisiopatologia
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