Size Distributions of Gold Nanoparticles in Solution Measured by Single-Particle Mass Photometry.

Specialized applications of nanoparticles often call for particular, well-characterized particle size distributions in solution, but this property can prove difficult to measure. High-throughput methods, such as dynamic light scattering, detect nanoparticles in solution with an efficiency that scales with diameter to the sixth power. This diminishes the accuracy of any determination that must span a range of particle sizes. The accurate classification of broadly distributed systems thus requires very large numbers of measurements. Mass-filtered particle-sensing techniques offer a better dynamic range but are labor-intensive and so have low throughput. Progress in many areas of nanotechnology requires a faster, lower-cost, and more accurate measure of particle size distributions, particularly for diameters smaller than 20 nm. Here, we present a tailored interferometric microscope system, combined with a high-speed image-processing strategy, optimized for real-time particle tracking that determines accurate size distributions in nominal 5, 10, and 15 nm colloidal gold nanoparticle systems by automatically sensing and classifying thousands of single particles sampled from solution at rates as high as 4000 particles per minute. We demonstrate this method by sensing the irreversible binding of gold nanoparticles to poly-d-lysine functionalized coverslips. Variations in the single-particle signal as a function of time and mass, calibrated by TEM, show clear evidence for the presence of diffusion-limited transport that most affects larger particles in solution.

Self-Assembled Functionally Graded Graphene Films with Tunable Compositions and Their Applications in Transient Electronics and Actuation.

The facile fabrication of functionally graded all-graphene films using a single-step casting process is reported. The films consist of a self-assembled graphene oxide (GO) precursor that can be reduced to different levels on an active metal substrate. Control of processing conditions such as the underlying substrate metal and the film-drying environment results in an ability to tailor the internal architecture of the films as well as to functionally grade the reduction of GO. A gradient arrangement within each film, where one side is electrically conductive reduced GO (rGO) and the other side is insulating GO, was confirmed by scanning electron microscopy, Raman, X-ray diffraction, Fourier transform infrared, and X-ray photoelectron spectroscopy characterization studies. All-graphene-based freestanding films with selectively reduced GO were used in transient electronic applications such as flexible circuitry and RFID tag antennas, where their decommissioning is easily achieved by capitalizing on GO's ability to readily dissociate and create a stable suspension in water. Furthermore, the functionally graded structure was found to exhibit differential swelling behavior, and its potential applications in graphene-based actuators are outlined.