1.
Org Lett
; 17(3): 564-7, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25615910
RESUMO
A novel synthesis of GSK1265744, a potent HIV integrase inhibitor, is described. The synthesis is highlighted by an efficient construction of the densely functionalized pyridinone core as well as a highly diastereoselective formation of the acyl oxazolidine moiety. The latter exploits the target molecule's ability to chelate to Mg(2+), a key feature in the integrase inhibitor's mechanism of action.