1.
Antibiotiki
; 26(8): 592-4, 1981 Aug.
Artigo
em Russo
| MEDLINE
| ID: mdl-7294751
RESUMO
A procedure for dry granulation of antibiotics consisting in dry compacting of a powder-like composition followed by its grinding to granules was developed. The advantages of dicloxacyllin capsules manufactured by dry granulation over the capsules manufactured by moist granulation are shown with respect to the content of the light absorbing admixtures during the capsule manufacture and storage. The conditions for estimation of the antibiotic dissolution from the capsule were developed with the use of a "Rotating Basket" apparatus. Comparative evaluation of disintegration and dissolution of the capsules prepared by dry or moist granulation showed practical equivalence of both types of the capsules with respect to these characteristics.