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1.
J Spinal Cord Med ; : 1-8, 2024 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-38391257

RESUMO

BACKGROUND: In our published randomized controlled trial, we revealed that patients with acute ASIA Grade C incomplete cervical spinal cord injury (SCI) who underwent early surgery (within 24 h post-injury) had accelerated motor recovery at six months than those with delayed surgery (>2 weeks post-injury); however, neuropathic pain (NeP) worsened regardless of surgery timing. Here, we conducted post-hoc analyses to intensively assess NeP development and maintenance. METHODS: Of 44 patients (median 64.5 years; three female; early intervention, n = 26), NeP was categorized into at-level and below-level pain and evaluated at  two weeks and one year after injury using the Neuropathic Pain Symptom Inventory (NPSI). We compared the two groups based on background characteristics. A mixed-design analysis of variance with sex as a covariate was conducted to analyze motor recovery and Health-related quality of life (HRQOL) in groups with severe (NPSI ≥ 10) or mild (NPSI < 10) pain. RESULTS: Upper and lower limb motor impairments were comparable between both groups regardless of pain severity. Severe at-level pain remained stable and worsened at one year than mild at-level pain; however, the upper- and lower-limb motor scores and HRQOL had comparable recovery. Background characteristics did not affect severity or time course of NeP. Patients with severe below-level pain demonstrated slower lower-limb motor recovery than those with mild below-level pain, whereas HRQOL improved regardless of pain severity. CONCLUSIONS: Both at-level and below-level NeP developed and persisted relatively early in the course of traumatic SCI with incomplete motor paralysis; their severities worsened over time or remained severe since onset.

2.
JAMA Netw Open ; 4(11): e2133604, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34751757

RESUMO

Importance: The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. Objective: To determine whether early surgical decompression results in better motor recovery than delayed surgical treatment in patients with acute traumatic incomplete cervical SCI associated with preexisting canal stenosis but without bone injury. Design, Setting, and Participants: This multicenter randomized clinical trial was conducted in 43 tertiary referral centers in Japan from December 2011 through November 2019. Patients aged 20 to 79 years with motor-incomplete cervical SCI with preexisting canal stenosis (American Spinal Injury Association [ASIA] Impairment Scale C; without fracture or dislocation) were included. Data were analyzed from September to November 2020. Interventions: Patients were randomized to undergo surgical treatment within 24 hours after admission or delayed surgical treatment after at least 2 weeks of conservative treatment. Main Outcomes and Measures: The primary end points were improvement in the mean ASIA motor score, total score of the spinal cord independence measure, and the proportion of patients able to walk independently at 1 year after injury. Results: Among 72 randomized patients, 70 patients (mean [SD] age, 65.1 [9.4] years; age range, 41-79 years; 5 [7%] women and 65 [93%] men) were included in the full analysis population (37 patients assigned to early surgical treatment and 33 patients assigned to delayed surgical treatment). Of these, 56 patients (80%) had data available for at least 1 primary outcome at 1 year. There was no significant difference among primary end points for the early surgical treatment group compared with the delayed surgical treatment group (mean [SD] change in ASIA motor score, 53.7 [14.7] vs 48.5 [19.1]; difference, 5.2; 95% CI, -4.2 to 14.5; P = .27; mean [SD] SCIM total score, 77.9 [22.7] vs 71.3 [27.3]; P = .34; able to walk independently, 21 of 30 patients [70.0%] vs 16 of 26 patients [61.5%]; P = .51). A mixed-design analysis of variance revealed a significant difference in the mean change in ASIA motor scores between the groups (F1,49 = 4.80; P = .03). The early surgical treatment group, compared with the delayed surgical treatment group, had greater motor scores than the delayed surgical treatment group at 2 weeks (mean [SD] score, 34.2 [18.8] vs 18.9 [20.9]), 3 months (mean [SD] score, 49.1 [15.1] vs 37.2 [20.9]), and 6 months (mean [SD] score, 51.5 [13.9] vs 41.3 [23.4]) after injury. Adverse events were common in both groups (eg, worsening of paralysis, 6 patients vs 6 patients; death, 3 patients vs 3 patients). Conclusions and Relevance: These findings suggest that among patients with cervical SCI, early surgical treatment produced similar motor regain at 1 year after injury as delayed surgical treatment but showed accelerated recovery within the first 6 months. These exploratory results suggest that early surgical treatment leads to faster neurological recovery, which requires further validation. Trial Registration: ClinicalTrials.gov Identifier: NCT01485458; umin.ac.jp/ctr Identifier: UMIN000006780.


Assuntos
Medula Cervical/lesões , Vértebras Cervicais/lesões , Descompressão Cirúrgica/estatística & dados numéricos , Traumatismos da Medula Espinal/cirurgia , Tempo para o Tratamento/estatística & dados numéricos , Adulto , Idoso , Medula Cervical/cirurgia , Vértebras Cervicais/cirurgia , Tratamento Conservador/estatística & dados numéricos , Descompressão Cirúrgica/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Desempenho Psicomotor , Recuperação de Função Fisiológica , Traumatismos da Medula Espinal/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
3.
Gastroenterol Nurs ; 41(3): 233-239, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28002078

RESUMO

Strong evidence exists regarding multiple benefits of physical activity among cancer patients. Patients undergoing esophagectomy received counseling for physical activity by a nurse and instructions to keep a diary of physical activities before surgery, followed by 2 counseling sessions after surgery. Physical activity, body mass index, psychological distress, and quality of life were measured at baseline, 2-4 weeks, and 3 and 6 months after discharge. Of 29 participants (mean age = 65.9 years), 72.5% underwent thoracoscopic esophagectomy in the prone position with 3-field lymphadectomy. The results of the International Physical Activity Questionnaire indicated that postoperative physical activity returned to nearly preoperative level, and the number of inactive patients gradually decreased by half at 6 months after discharge. Quality of life scores, except those for role function and social function, tended to return to the baseline at 6 months after discharge. Psychological distress measured by the Kessler 6 remained lower than the baseline, whereas the mean score of body mass index gradually declined after discharge. Patients undergoing esophagectomy and receiving nurse counseling can return to preoperative physical activity level in their daily lives after surgery. Nurses should integrate physical activity promotion into cancer care.


Assuntos
Aconselhamento Diretivo/métodos , Neoplasias Esofágicas/cirurgia , Esofagectomia/métodos , Exercício Físico/fisiologia , Atividades Cotidianas , Adulto , Idoso , Estudos de Coortes , Neoplasias Esofágicas/patologia , Esofagectomia/enfermagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/métodos , Papel do Profissional de Enfermagem , Cuidados Pós-Operatórios/métodos , Prognóstico , Qualidade de Vida , Recuperação de Função Fisiológica , Estudos Retrospectivos
4.
Trials ; 14: 245, 2013 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-23924165

RESUMO

BACKGROUND: The optimal management of acute cervical spinal cord injury (SCI) associated with preexisting canal stenosis remains to be established. The objective of this study is to examine whether early surgical decompression (within 24 hours after admission) would result in greater improvement in motor function compared with delayed surgery (later than two weeks) in cervical SCI patients presenting with canal stenosis, but without bony injury. METHODS/DESIGN: OSCIS is a randomized, controlled, parallel-group, assessor-blinded, multicenter trial. We will recruit 100 cervical SCI patients who are admitted within 48 hours of injury (aged 20 to 79 years; without fractures or dislocations; American Spinal Injury Association (ASIA) grade C; preexisting spinal canal stenosis). Patients will be enrolled from 36 participating hospitals across Japan and randomly allocated in a 1:1 ratio to either early surgical decompression (within 24 hours after admission) or delayed surgery following at least two weeks of conservative treatment. The primary outcomes include: 1) the change from baseline to one year in the ASIA motor score; 2) the total score of the Spinal Cord Independence Measure and 3) the proportion of patients who are able to walk without human assistance. The secondary outcomes are: 1) the health-related quality of life as measured by the Medical Outcomes Study Short Form 36 and the EuroQol 5 Dimension; 2) the Neuropathic Pain Symptom Inventory and 3) the walking status as evaluated with the Walking Index for Spinal Cord Injury II. The analysis will be on an intention-to-treat basis. The primary analysis will be a comparison of the primary and secondary outcomes one year after the injury. DISCUSSION: The results of this study will provide evidence of the potential benefit of early surgical decompression compared to the current 'watch and wait' strategy.


Assuntos
Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Procedimentos Ortopédicos/métodos , Projetos de Pesquisa , Traumatismos da Medula Espinal/cirurgia , Estenose Espinal/cirurgia , Doença Aguda , Adulto , Idoso , Protocolos Clínicos , Descompressão Cirúrgica/efeitos adversos , Avaliação da Deficiência , Feminino , Humanos , Análise de Intenção de Tratamento , Japão , Masculino , Pessoa de Meia-Idade , Atividade Motora , Procedimentos Ortopédicos/efeitos adversos , Medição da Dor , Valor Preditivo dos Testes , Qualidade de Vida , Recuperação de Função Fisiológica , Traumatismos da Medula Espinal/diagnóstico , Traumatismos da Medula Espinal/etiologia , Traumatismos da Medula Espinal/fisiopatologia , Estenose Espinal/complicações , Estenose Espinal/diagnóstico , Estenose Espinal/fisiopatologia , Inquéritos e Questionários , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
5.
J Artif Organs ; 16(2): 170-5, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23238557

RESUMO

To control particle-induced osteolysis in total hip replacement (THR), we developed a new technique to graft poly(2-methacryloyloxyethyl phosphorylcholine) onto the surface of polyethylene liners. A prospective cohort study was conducted to investigate the clinical safety of this novel bearing surface. Between April 2007 and September 2008, we recruited a prospective consecutive series of 80 patients in five participating hospitals. These patients received a cementless THR; a 26-mm-diameter cobalt-chromium-molybdenum alloy ball and a poly(2-methacryloyloxyethyl phosphorylcholine)-grafted cross-linked polyethylene liner were used for the bearing couplings. These individuals were followed a year postoperatively. An evaluation of clinical performance was conducted through an assessment of hip joint function based on the evaluation chart authorized by the Japanese Orthopaedic Association. No patients were lost to follow-up. No adverse events were found to be correlated with the implanted liners. The average hip joint function score improved from 43.2 preoperatively to 91.7 postoperatively at 1 year. There was no implant migration nor periprosthetic osteolysis detected on radiographic analysis. On the basis of our results, we conclude that poly(2-methacryloyloxyethyl phosphorylcholine)-grafted cross-linked polyethylene liners are a safe implant option for hip replacement surgery for short-term clinical use.


Assuntos
Artroplastia de Quadril/instrumentação , Prótese de Quadril , Metacrilatos , Fosforilcolina/análogos & derivados , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polietilenos , Ácidos Polimetacrílicos , Complicações Pós-Operatórias , Estudos Prospectivos , Desenho de Prótese , Resultado do Tratamento
6.
Fam Cancer ; 10(4): 649-54, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21695501

RESUMO

Lynch syndrome (HNPCC) is an autosomal dominant hereditary cancer syndrome, and members of affected families are at-risk for developing colorectal and other associated tumors. Such individuals should disseminate familial genetic information, so they can seek specific medical assessment or genetic testing to reduce mortality and morbidity rates by early detection. Since published results have been encouraging, we explored which factors influence the likelihood of good communication within families regarding medical assessment. We studied 40 individuals from 33 families who satisfied the Japanese clinical criteria for Lynch syndrome and their relatives at our hospital. We determined the status of relatives of the 40 individuals after genetic counseling and testing using questionnaires and semi-structured interviews based on pedigree charts. We also examined their knowledge or perception of colorectal cancer syndrome, levels of intimacy and whether or not they encouraged their relatives to have specific medical assessments. We found that 75% of the individuals advised their relatives to seek medical assessment, and any significant background factors that promoted such encouragement were observed. They tended to encourage first degree relatives and discuss the issue with other family members such as spouses before undertaking such attempts at encouragement. The reasons and methods of imparting encouragement were essentially identical. We also found that genetic testing for at-risk or more distant relatives was not encouraged so often. Therefore, providing individuals who have been tested for Lynch syndrome with opportunities for disseminating familial genetic information through appropriate genetic counseling is important.


Assuntos
Neoplasias Colorretais Hereditárias sem Polipose/psicologia , Relações Familiares , Aconselhamento Genético/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Comunicação , Feminino , Testes Genéticos , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Medição de Risco , Apoio Social
7.
Support Care Cancer ; 18(11): 1393-403, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19841949

RESUMO

PURPOSE: Little research has been done on supportive needs of cancer patients in acute hospitals in Japan. This study aims to comprehensively assess the unmet supportive needs of hospitalized cancer patients, as well as literacy and utilization of appropriate professional care. METHODS: All cancer patients (aged 20 to 80 years) who were hospitalized in a university hospital in Tokyo during the designated 3-day period between September 1 and October 31, 2007 were recruited for participation in the study. The M.D. Anderson Symptom Inventory, Brief Cancer-Related Worry Inventory, and Hospital Anxiety and Depression Scale were administered. Patients' knowledge and use of relevant services were evaluated. The results were compared with those of non-cancer patients in the same treatment settings. RESULTS: A total of 125 cancer patients and 59 non-cancer patients were enrolled. Cancer patients and non-cancer patients equally suffered from physical symptoms (15-26% had severe appetite loss, 18-19% had severe dry mouth, and 16-22% had severe pain); however, psychological distress of cancer patients exceeded that of non-cancer patients (28.0% vs 8.5%; p ≤ 0.05). Severe psychological distress was associated with severe worry about future prospects or interpersonal and social issues and presence of two or more severe symptoms. Two thirds of the patients with severe psychological distress knew about the psychiatric division, but only one third actually sought treatment. CONCLUSIONS: Needs related to psychological issues were more prevalent among cancer patients than among non-cancer patients, despite a similar level of physical distress. Special attention should be paid to cancer patients who worry over future prospects or interpersonal and social issues, and those who have two or more severe symptoms.


Assuntos
Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Neoplasias/psicologia , Estresse Psicológico/terapia , Idoso , Estudos de Casos e Controles , Feminino , Hospitalização , Hospitais Universitários , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Avaliação das Necessidades , Psicometria , Índice de Gravidade de Doença , Estresse Psicológico/etiologia , Inquéritos e Questionários
8.
Am J Hosp Palliat Care ; 24(3): 202-10, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17601844

RESUMO

The aim of this study was to clarify the relationship of nursing autonomy and other factors related to attitudes toward caring for dying patients. A cross-sectional survey of nurses was conducted in November 2003 using a self-administered questionnaire. We collected demographic data from 178 (75%) participants and used the Frommelt Attitude Toward Care of the Dying scale, Form B, Japanese version (FATCOD-Form B-J), the Pankratz Nursing Questionnaire (PNQ), and the Death Attitude Inventory (DAI). FATCOD-Form B-J measures nurse's attitude toward caring for dying patients. It includes two subscales: positive attitude toward caring for the dying patient and perception of patient- and family-centered care. The PNQ measures nursing autonomy of individual nurses and has three subscales: nursing autonomy and advocacy, patients' rights, and rejection of traditional role limitations. The DAI measures attitudes toward death in context of Japanese cultural characteristics. It includes seven subscales: afterlife beliefs, death anxiety, death relief, death avoidance, life purpose, death concern, and supernatural beliefs. We investigated the factors associated with the FATCOD-Form B-J. Support of a mentor regarding end-of-life issues (beta = .19, P = .001), death avoidance domain of the DAI (beta = -.14, P = 0.03), life purpose domain of the DAI (beta = .23, P = .001), and rejection of traditional role limitations domain of the PNQ (beta = .51, P = .001) were selected as significant independent variables by multivariate analysis to evaluate nurses' positive attitudes toward caring for dying patients. Death anxiety domain of the DAI (beta = -.17, P = .02), patients' rights domain of the PNQ (beta =.46, P = .001), and rejection of traditional role limitations domain of the PNQ (beta = .34, P = .001) were selected as significant independent variables by multivariate analysis to evaluate the nurses' perception of patient-and family-centered care. In conclusion, nursing autonomy plays an important role in the attitudes of Japanese nurses who care for dying patients. Educational and administrative efforts to strengthen nursing autonomy are necessary.


Assuntos
Atitude do Pessoal de Saúde , Enfermagem , Autonomia Profissional , Assistência Terminal , Adulto , Estudos Transversais , Educação em Enfermagem , Enfermagem Familiar , Feminino , Humanos , Japão , Masculino , Análise Multivariada , Assistência Centrada no Paciente
9.
Support Care Cancer ; 15(7): 801-6, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17180394

RESUMO

GOAL: Although the importance of the palliative care team (PCT) to university hospitals is widely accepted, the issues of palliative care at the national level have not been clarified. We conducted a nationwide survey of the current status of PCTs in all (123) Japanese university hospitals. MATERIALS AND METHODS: In 2003, 2004 and 2005, the authors conducted a self-reporting cross-sectional survey. Questionnaires were mailed to nursing directors and selected PCT members of all Japanese university hospitals. RESULTS: Of 123 hospitals in 2005, 99 (80%) returned the questionnaire; 33% used PCTs, and 11% used certified PCTs. Our findings include: annual number of patients treated by PCTs (83/70 +/- 64, mean/median +/- SD), daily number of patients treated by PCTs (12/11 +/- 14), and days of PCT care per patient (30/30 +/- 22). Certified PCTs treated more patients per year (p = 0.004) and more patients per day (p < 0.001) compared to noncertified PCTs. Over the 3-year period, the number of hospitals utilizing PCTs only slightly increased (2003: 27%, 2004: 29%, 2005: 33%), as did those using certified PCTs (2003: 3%, 2004: 9%, 2005: 11%). In 2005, the reasons for noncertification of PCTs included "lack of physicians who specialize in palliative care (82%)" and "lack of nurses who specialize in palliative care (56%)." CONCLUSIONS: The entire system of palliative care in Japanese university hospitals is currently insufficient. The lack of physicians and nurses who specialize in palliative care is a significant barrier, and therefore, the initiation of a formal training system for these health care professionals is a high priority issue.


Assuntos
Hospitais Universitários , Neoplasias/psicologia , Cuidados Paliativos , Equipe de Assistência ao Paciente , Estudos Transversais , Pesquisas sobre Atenção à Saúde , Humanos , Japão , Medição da Dor , Inquéritos e Questionários
10.
J Orthop Sci ; 11(4): 359-64, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16897199

RESUMO

BACKGROUND: The Nottingham Adjustment Scale-Japanese version (hereinafter referred to as NAS-J) was developed to measure psychological adaptation to visually impairment. Several disease-specific modified versions have been developed in Japan. The purpose of this study was to develop and test the reliability, validity, and responsiveness of the NAS-J for hip osteoarthritis patients. METHODS: Patients with osteoarthritis of the hip managed as outpatients at the Department of Orthopaedic Surgery of one university hospital gave informed written consent to be enrolled in this study. Subjects were asked to complete a questionnaire consisting of the NAS-J--Hip edition (hereinafter referred to as NAS-J-HIP), health-related QOL (Short Form 36). Subjects' medical and treatment histories, and the Japanese Hip Society's Evaluation Chart of Hip Joint Functions (hereinafter referred to as the JOA score) were also collected from their medical records. Psychometric analyses were conducted to test reliability, validity, and responsiveness. RESULTS: A total of 231 patients agreed to participate in the survey, and responses were obtained from 168 (72.7%). Their mean +/- SD age was 52.5 +/- 12.4 years, and the mean JOA score was 80.9 points. By factor analysis using the principal factor method, seven factors were extracted: (1) anxiety/depression, (2) self-esteem, (3) attitude, (4) locus of control, (5) acceptance, (6) self-efficacy, and (7) attributional style. Concurrent validity was the result according to the near hypothesis. Cronbach's alpha-coefficient ranged from 0.68 to 0.83, indicating high internal consistency. CONCLUSIONS: For hip osteoarthritis patients, construct validity was confirmed for NAS-J-HIP. Furthermore, seven factors comprising 27 items with high internal consistency were incorporated into NAS-J-HIP. This scale can be used to assess the psychological adaptation of hip osteoarthritis patients.


Assuntos
Adaptação Psicológica , Osteoartrite do Quadril/psicologia , Inquéritos e Questionários , Adulto , Idoso , Análise Fatorial , Feminino , Indicadores Básicos de Saúde , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Psicometria
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