RESUMO
BACKGROUND: Graft-versus-host disease (GVHD) is the most common and most serious complication of allogeneic hematopoetic stem cell transplantation (HSCT). The aim of this study was to assess the incidence of GVHD after allogeneic HSCT depending on the diagnosis and risk factors. MATERIAL AND METHODS: The study group comprised 78 patients aged 18 to 61 in whom allogeneic transplantation of hematopoietic stem cell in the Department and Clinic of Hematology, Oncology and Internal Diseases of Medical University in Warsaw (Poland) was performed. RESULTS: Acute form of GVHD was significantly more often occurred after total body irradiation (TBI) for patients with TBI who did not (p < 0.05). CONCLUSIONS: Risk factors for aGVHD were: age of the recipient, acute myeloid leukemia, myeloablative conditioning, TBI and unrelated donor.
Assuntos
Doença Enxerto-Hospedeiro/epidemiologia , Transplante de Células-Tronco Hematopoéticas/estatística & dados numéricos , Transplante de Células-Tronco/estatística & dados numéricos , Transplante Homólogo/estatística & dados numéricos , Adolescente , Adulto , Idoso , Causalidade , Feminino , Doença Enxerto-Hospedeiro/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Polônia/epidemiologia , Fatores de Risco , Transplante de Células-Tronco/efeitos adversos , Transplante Homólogo/efeitos adversos , Irradiação Corporal Total/efeitos adversos , Irradiação Corporal Total/estatística & dados numéricos , Adulto JovemRESUMO
Myeloablative chemotherapy used prior stem cell transplantation produces epithelial injury including oral cavity. Both damage by chemotherapy and subsequent infections cause mucositis. The aim of the study was to evaluate mucositis in a group of 31 patients. Patients aged 18-67 yrs (mean 42 yrs): 28 with blood neoplasms and 3 with aplastic anemia, were observed on days 0, 3, 5, 7, 9, 14 and 30 after transplantation of haematopoietic cells (autologous in 20 cases and allogeneic in 11 cases). The intensity of mucosal inflammation was evaluated according to 3 scales: WHO, Bearmann and 5-degree scale developed by the authors. This last scale, unlike other scales, was based on an accurate stomatological evaluation of the mucosal changes. A positive correlation was found between the intensity of mucosal inflammation and granulocytopenia <500/microl (p<0.01) and also between the presence of petechiae with blood platelet level <20.000/microl (p<0.001).
