RESUMO
Aromatic hydrocarbons are rightly considered to belong to most active synthetic interferon inducers among low molecular compounds. A comparative evaluation of L-1 (acridanon) and amixin (fluorenon) showed L-1 to have more marked interferon-inducing properties. Both compounds differed not only in the dynamics and levels of interferon synthesis in different organs which suggests the possibility of their employment in different diseases, but also in the efficacy of the modes of application. L-1 induced IF synthesis most actively after subcutaneous inoculation, amixin after oral administration.
Assuntos
Indutores de Interferon/farmacologia , Compostos Policíclicos/farmacologia , Acridinas/administração & dosagem , Acridinas/farmacologia , Administração Oral , Animais , Relação Dose-Resposta a Droga , Injeções Intraperitoneais , Injeções Subcutâneas , Indutores de Interferon/administração & dosagem , Interferons/análise , Células L , Camundongos , Camundongos Endogâmicos CBA , Compostos Policíclicos/administração & dosagem , Tilorona/administração & dosagem , Tilorona/farmacologiaRESUMO
Based on clinicopsychopathological and paraclinical examinations of 150 patients afflicted with organic diseases of the brain of infectious, traumatic and alcoholic nature, the clinical picture and formation of hypochondriac conditions were traced depending on the type of exogeny and the stage of cerebral sufferings. It is shown that hypochondriac conditions develop by stages, namely from hypochondriac fixation to hypochondriac reaction and to the hypochondriac syndrome and that psychasthenic, vasovegetative and CSF dynamic disorders play the leading part in their establishment. Seven varieties of the hypochondriac syndrome are distinguished.
Assuntos
Alcoolismo/psicologia , Encefalopatias/psicologia , Hipocondríase/etiologia , Transtornos Neurocognitivos/etiologia , Alcoolismo/complicações , Encefalopatias/complicações , Terapia Combinada , Humanos , Hipocondríase/classificação , Hipocondríase/terapia , Transtornos Neurocognitivos/classificação , Transtornos Neurocognitivos/terapiaRESUMO
Data on synthesis of new polymer compounds with potential interferon-inducing and antiviral activity are presented. Maleic anhydride (MA)-based alternating copolymers, in particular, copolymers of divinyl ether with MA containing five-member oxygen cycles in the chain, as well as furan copolymers with MA, were shown to be promising interferon inducers. The antiviral activity was found in copolymers based on allene hydrocarbons.