Experimental membrane-destructive model of cardiac arrhythmia.

We propose a method for experimental modeling of cardiac arrhythmias. The method consists in intravenous injection of LPO inductors: 5% ascorbic acid (50 mg/kg), 1 min later 1% iron sulfate (10 mg/kg), and after the appearance of giant T waves on ECG infusion of 10% calcium chloride in a nonarrhythmogenic dose 100 mg/kg. Cardiac arrhythmias were induced in 100% animals. A significant relationship between increased permeability of erythrocyte membranes and development of fatal cardiac arrhythmias was detected. We assumed that this methodologically simple membrane-destructive model of cardiac arrhythmia is pathogenetically close to arrhythmogenesis in patients with coronary heart disease.

[The study and comparative evaluation of the actoprotective activity of ATF-LONG in experiment]. / Izuchenie i sravnitel'naia otsenka aktoprotektornoi aktivnosti ATF-LONG v éksperimente.

In the paper, results are reflected of a swimming test in 78 laboratory rats. ATF-LONG has been shown to be capable of augmenting the animals' powers of endurance during loading tests. The established dose-dependent actoprotective activity of ATF-LONG is superior to that of adenosine triphosphate, trimetasidine (preductal), and mildronate. Possible pharmacological mechanisms of its actoprotective activity are discussed. The authors come to the conclusion that performance capability gets improved under exposure to purine nucleotides.

[The working classification of antiarrhythmic drugs based on the pathogenetic approach to treatment of cardiac arrhythmias]. / O rabochei klassifikatsii antiaritmicheskikh preparatov, osnovannoi na patogeneticheskom printsipe lecheniia narushenii ritma serdtsa.

Classification of antiarrhythmic drugs was proposed by E. Williams and updated by D. Harrison in those days when antiarrhythmic activity of activators of the heart's receptors and ionic pumps was studied hardly at all and effect on the sarcolemma's bilipid layer, permiability was not regarded as a method of correction of bioelectrical instability of the myocardium. The authors propose that antiarrhythmic drugs should be considered in four categories: the modulators of ionic channels, the modulators of receptors of the heart, the modulators of ionic pumps, and membrane-protecting agents, with each category subdivided into subclasses and groups of drug preparations.

[Physiological and hygienic characteristics of working conditions in the copper and nickel-processing industry]. / Fiziologo-gigienicheskaia kharakteristika uslovii truda metallurgov v proizvodstve medi i nikelia.

Basing on complex physiological and hygienic studies, the contributors propose an assessment of the work load of those engaged in the major professions in copper and nickel metallurgy. The results of the study revealed a significant functional overstrain in workers, which resulted from manual labour overload, unfavourable microclimate conditions (hot in summer and cold in winter), along with a set of hazardous factors (dusts, toxic gases, etc). A set of health-related measures was proposed.