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Drug Discov Today ; 29(6): 104009, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38692505

RESUMO

AI techniques are making inroads into the field of drug discovery. As a result, a growing number of drugs and vaccines have been discovered using AI. However, questions remain about the success of these molecules in clinical trials. To address these questions, we conducted a first analysis of the clinical pipelines of AI-native Biotech companies. In Phase I we find AI-discovered molecules have an 80-90% success rate, substantially higher than historic industry averages. This suggests, we argue, that AI is highly capable of designing or identifying molecules with drug-like properties. In Phase II the success rate is ∼40%, albeit on a limited sample size, comparable to historic industry averages. Our findings highlight early signs of the clinical potential of AI-discovered molecules.


Assuntos
Inteligência Artificial , Ensaios Clínicos como Assunto , Descoberta de Drogas , Humanos , Ensaios Clínicos como Assunto/métodos , Descoberta de Drogas/métodos , Indústria Farmacêutica
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