[Sex and changes in mu-opioid receptor density under hypoxia]. / Plec a zmiany w gestosci receptorów ukladu opioidowego pod wplywem niedotlenienia.

The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The density and distribution of mu-opioid receptors in MPOA is cyclical and sexually dimorphic. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in fetus brain in both sexes differentially, we performed the following study. We divided 24 pregnant Sprague-Dawley rats to two treatment groups and control group. We exposed one group (CH) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. We analyzed the brain regions: CPu, ZG, NA, OT, MMPoA, LMPoA by quantitative autoradiography following incubation with (3H) DAMGO. We didn't notice any significant changes in mu-opioid receptor density between sexes in selected brain regions. We found mu-opioid receptor a significant changes in mu-opioid receptor of all brain regions in female group.

[Analysis of twin pregnancies in material from the Department of Obstetrics and Pathology of Pregnancy in Lublin from 1991-1998]. / Analiza ciaz blizniaczych w materiale Kliniki Poloznictwa i Patologii Ciazy AM w Lublinie w latach 1991-1998.

The course of multiple pregnancies and multiple fetus labor were analyzed in 111 women delivered in the Department of Obstetrics, School of Medicine in Lublin in the years 1991-1998. It has been found that the most frequent patients were those aged 25-29 coming from the cities and after the infertility treatment. The aim of this research was to characterize twin pregnant patients, and present the outcome of multiple pregnancy. The studies were performed on 67 women from the cities and 44 women from the villages. It is significant that almost 55% pregnant women underwent the cesarean section and their average birth weight was 2490 g. These results indicate that multiple pregnancy is in high risk pregnancy.

[Comparison of changes in optical density of mu-opioid receptors in the brain of adult rats after prenatal and postnatal hypoxia]. / Porównanie zmian w gestosci optycznej receptorów mu-opioidowych w mózgach doroslych szczurów pod wplywem przebytego niedotlenienia przedporodowego i poporodowego.

UNLABELLED: The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The early development of the opioid receptor system has been reported to be susceptible to perinatal opioid exposure so the developing brain may be influenced by circulating opioids. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in developing brain, we performed the following study. We divided 36 pregnant Sprague-Dawley rats to three treatment groups and control group. We exposed one group (C) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. Group of newborns (PH) we exposed to postnatal hypoxia (10.5% O2) from day P2-10. We analyzed the several brain regions: CPu, NA, MMPoA, LMPoA, CA3, VM, AH, Habenula by quantitative autoradiography following incubation with (3H) DAMGO. RESULTS: 1) Chronic prenatal hypoxia decreased mu-receptor binding in all brain regions examined. 2) In contrast, mu-receptor binding following acute, intermittent hypoxia tended to be increased in the several brain regions. 3) Postnatal hypoxia did not change mu-receptor binding in characteristic way. 4) Such receptor changes may be associated with endocrinologic or behavioral abnormalities.

[Amniotic band syndrome: a case study]. / Zespól tasm owodniowych--opis przypadku.

This study present a case of a female newborn, gestational age (GA)--27 weeks, birth weight--1020 g (50 percentile), body length--38 cm, head circumference--26 cm, chest circumference--24 cm. The newborn came from the first pregnancy, the amniotic fluid leak was observed for 7 days before delivery resolved by cesarean section. The following consequences of the amniotic band syndrome were observed in the newborn: congenital amputation of lower left limb, congenital amputation of 2nd, 3rd, 4th, 5th fingers in the upper right limb, congenital constricting ring of 1 finger in the upper right limb, congenital amputation of 1st toe in the lower right limb, syndactylism of fingers of upper and lower limbs. The above malformations will be presented and supported by photographic, ultrasound and radiographic documentation.

[Multiple malformations syndrome: a case report]. / Zespól wad wrodzonych--opis przypadku.

We described a case with multiple congenital malformations diagnosed at 35 weeks of pregnancy by ultrasound examinations.

[Cerclage of the cervix in pregnant women with cervix incompetence in the Department of Obstetrics and Pathology of Pregnancy, School of Medicine in Lublin during the years 1982-188]. / Szew okrezny szyjki macicy u kobiet z niewydolnoscia ciesniowo-szyjkowa rodzacych w Klinice Poloznictwa i Patologii Ciazy AM w Lublinie w latach 1982-1988.

We have retrospectively analyzed 77 cases of pregnant patients with cervical incompetence in which we performed cervical cerclage. These cases were 0.65% of all deliveries. The age was 20-41 years (mean 28.5). They were in second or third pregnancy. 62 women delivered by vaginal way and 15 by cesarean section. Only 5 newborn had small weight for age. We discussed our results with data from other authors.