RESUMO
The NIH All of Us Research Program, a national effort to collect biospecimens and health data for over one million participants from across the United States, requires participating healthcare provider organizations (HPOs) to use informatics tools maintained by the NIH to manage participant consent, biospecimen processing, physical measurements, and other workflows. HPOs also maintain distinct workflows for handling overlapping tasks within their individual aegis, which do not necessarily achieve seamless interoperability with NIH-maintained cloud-based systems. At our HPO, we implemented informatics to address gaps in enrollment workflows and hardware, clinical workflow integration, patient engagement, laboratory support, and study team reporting. In this case report we detail our approach to inform efforts at other institutions for the NIH All of Us Research Program and other studies.
RESUMO
To enable clinical and translational research, academic medical centers increasingly implement biospecimen information management systems. At our institution, one laboratory successfully implemented a multi-system solution that enabled collection and reporting of specimen- and aliquot-level data. The objective of this study was to assess the solution against the laboratory's requirements and with respect to support of best practices for biospecimen information management systems defined by the International Society for Biological and Environmental Repositories (ISBER). The solution supported the laboratory's reporting needs and 90% (n=26) of ISBER best practices. To the best of our knowledge, this is among the first studies to demonstrate the generalizability of a biospecimen informatics approach. Findings suggest that development and evaluation of biospecimen informatics approaches can potentially improve through closer collaboration of informatics and biorepository professional societies.
