In vivo cardiac phase response curve elucidates human respiratory heart rate variability.

Recovering interaction of endogenous rhythms from observations is challenging, especially if a mathematical model explaining the behaviour of the system is unknown. The decisive information for successful reconstruction of the dynamics is the sensitivity of an oscillator to external influences, which is quantified by its phase response curve. Here we present a technique that allows the extraction of the phase response curve from a non-invasive observation of a system consisting of two interacting oscillators--in this case heartbeat and respiration--in its natural environment and under free-running conditions. We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of 17 healthy humans. We show for the first time the phase at which the cardiac beat is susceptible to respiratory drive and extract the respiratory-related component of heart rate variability. This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.

Detecting triplet locking by triplet synchronization indices.

We discuss the effect of triplet synchrony in oscillatory networks. In this state the phases and the frequencies of three coupled oscillators fulfill the conditions of a triplet locking, whereas every pair of systems remains asynchronous. We suggest an easy to compute measure, a triplet synchronization index, which can be used to detect such states from experimental data.

Optimal phase description of chaotic oscillators.

We introduce an optimal phase description of chaotic oscillations by generalizing the concept of isochrones. On chaotic attractors possessing a general phase description, we define the optimal isophases as Poincaré surfaces showing return times as constant as possible. The dynamics of the resultant optimal phase is maximally decoupled from the amplitude dynamics and provides a proper description of the phase response of chaotic oscillations. The method is illustrated with the Rössler and Lorenz systems.

Reconstructing phase dynamics of oscillator networks.

We generalize our recent approach to the reconstruction of phase dynamics of coupled oscillators from data [B. Kralemann et al., Phys. Rev. E 77, 066205 (2008)] to cover the case of small networks of coupled periodic units. Starting from a multivariate time series, we first reconstruct genuine phases and then obtain the coupling functions in terms of these phases. Partial norms of these coupling functions quantify directed coupling between oscillators. We illustrate the method by different network motifs for three coupled oscillators and for random networks of five and nine units. We also discuss nonlinear effects in coupling.

Phase dynamics of coupled oscillators reconstructed from data.

We systematically develop a technique for reconstructing the phase dynamics equations for coupled oscillators from data. For autonomous oscillators and for two interacting oscillators we demonstrate how phase estimates obtained from general scalar observables can be transformed to genuine phases. This allows us to obtain an invariant description of the phase dynamics in terms of the genuine, observable-independent phases. We discuss the importance of this transformation for characterization of strength and directionality of interaction from bivariate data. Moreover, we demonstrate that natural (autonomous) frequencies of oscillators can be recovered if several observations of coupled systems at different, yet unknown coupling strengths are available. We illustrate our method by several numerical examples and apply it to a human electrocardiogram and to a physical experiment with coupled metronomes.

Uncovering interaction of coupled oscillators from data.

We develop a technique for reconstructing the phase dynamics equations for weakly coupled oscillators from data. We show how, starting from general scalar observables, one can first reconstruct the dynamics in terms of the corresponding protophases, and then, performing a transformation to the genuine, observable-independent phases, obtain an invariant description of the phase dynamics. We demonstrate that natural frequencies of oscillators can be recovered if several observations of coupled systems at different coupling strengths are available. We apply our theory to numerical examples and to a physical experiment with coupled metronomes.