RESUMO
Bacterial endotoxins administered to BALB/c mice given i.p. mineral oil cause an increased incidence of plasma cell tumors, compared with mice given either oil or antigens alone, or oil plus antigen other than endotoxin. Endotoxin in ng doses was more effective than in mug doses.
Assuntos
Endotoxinas/farmacologia , Óleo Mineral , Plasmocitoma/induzido quimicamente , Animais , Endotoxinas/administração & dosagem , Eritrócitos/imunologia , Escherichia coli/imunologia , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Transplante de Neoplasias , Neoplasias Experimentais/induzido quimicamente , Salmonella typhimurium/imunologia , Soroalbumina Bovina/farmacologia , Transplante HomólogoRESUMO
Small amounts (0.1 ng to 5.0 mug) of Escherichia coli endotoxin protect normal female BALB/c mice against challenge with low doses of syngeneic mineral oil-induced 315 plasma cell tumor. Significant protection was most evident when mice were treated with endotoxin 11 days and 5 days before inoculation with 50 to 100 tumor cells i.p., and endotoxin treatment continued twice a week for the entire experiment. Tumors induced by 10,000 cells s.c. were similarly affected by this treatment. The antitumor action of endotoxin was obliterated when higher challenges of tumor cells or solid tumor pieces were used. Omission of endotoxin pretreatment resulted in a loss of the effect against i.p.-induced tumors but not against s.c.-induced tumor.
