RESUMO
Experimental facts about influence of new beta-1-3;1-6-glucan, extracted from seaweed Laminaria, on immune response of mice are summarized. The ability of translam to increase the number and functional activity of immunocompetent cells taking part in humoral immune response formation. The possibility of translam using for treatment and prophylaxis of radiation affections is discussed.
Assuntos
Reações Antígeno-Anticorpo/efeitos dos fármacos , Glucanos/farmacologia , Polissacarídeos/farmacologia , Animais , Reações Antígeno-Anticorpo/imunologia , Linfócitos B/efeitos dos fármacos , Linfócitos B/imunologia , Linfócitos B/efeitos da radiação , Radioisótopos de Cobalto , Imunização , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Baço/efeitos dos fármacos , Baço/imunologia , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologia , Linfócitos T/efeitos da radiação , Fatores de TempoRESUMO
It has been studied the influence of translam-beta-1,3; 1,6-glucan, extracted from seaweed Laminaria, on the isolation of E. coli from spleen and on the functional activity of peritoneal macrophages of sublethal irradiated and infected mice. It has been shown the reduction of the number of microbes, isolated from spleen and stimulation of ingestive and digestive activity of macrophages following the introduction of translam in mice. This results show about the increase of natural resistance of irradiated organism under translam action and characterise this glucan as effective stimulator of immunity.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Glucanos/uso terapêutico , Lesões Experimentais por Radiação/tratamento farmacológico , Protetores contra Radiação/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/imunologia , Raios gama , Imunidade Inata/efeitos dos fármacos , Laminaria , Camundongos , Fagocitose/efeitos dos fármacos , Lesões Experimentais por Radiação/complicações , Lesões Experimentais por Radiação/imunologia , Fatores de TempoRESUMO
The authors presented experimental data on the assessment of radiation pathomorphosis of squamous cell carcinoma (RShM-2) in mice after single total irradiation at a dose of --Gy using radiomodifiers in various combinations. Blood flow inhibition used independently was shown to be and important factor in the implementation of the radiation antitumor effect. Good results were obtained in the combined use of blood flow inhibition and short-term induced hyperglycemia, the best results were achieved with the combined use of radiomodifiers during blood flow inhibition.
